The aim of this project was to assess the immunomodulatory capabilities of a bank of 46 dairy fermentates derived from lactic acid bacteria. Initially screening the 46 fermentates in the context of viral immunity assessing their viability, and cytokine secretion profiles in JAWS and bone marrow derived dendritic cells (BMDC), highlighted 4 immune boosting candidates Aerobic R0033, R0419, SC40, and Anaerobic R0033. A more in depth screening was carried out on these fermentates to assess their eSect in additional immune cells key to innate immunity, macrophage cell line J774.A.1 and primary bone marrow derived macrophage (BMDM). A range of cell functions were assessed including cell viability, cytokine and chemokine secretion, phagocytosis, and cell surface marker expression. A multidisciplinary review from Food for health Ireland (FHI), and its collaborators collated the top 19 fermentates in the context of candidate anti-inflammatory samples to support gut health. An initial screening assessed these 19 fermentates in the context of anti-inflammatories assessing cell viability and cytokine secretion in both BMDM, and BMDCs, to highlight 4 candidate anti-inflammatory fermentates. The top 5 immune boosting and anti-inflammatory fermentates were deduced and a comparative screening in BMDC, highlighted the top 4 candidates, two immune boosting (Aerobic R0033, R0419) and two anti-inflammatory fermentates (SC40, LH88). Theses fermentates were assessed for nitric oxide production, arginase activity, and cytokine secretion in unpolarised and M1, M2 polarised macrophage, to highlight the two most promising immune boosting and anti-inflammatory fermentate, Aerobic R0033, and SC40 respectively. These two samples underwent extensive analysis in murine derived naïve, Th1, Th2, Th17, and Treg cells for viability, and cytokine secretion to establish sample eSect on adaptive immunity. From there these two samples were assessed for their eSect on cell functionality in the human T cell line JURKAT cells, assessing their eSect on cytokine secretion, cell proliferation, cell migration, immune synapse interactions, and downstream signalling. This project highlighted sample Aerobic R0033, and SC40 as the most promising fermentates for their immune boosting, and anti-inflammatory capabilities respectively.