This study explores the strategies HIV and Hepatitis C activists within civil society organisations used to fight for their right to medicines before and after the Euromaidan Revolution. The literature review brings together the latest research on social-political determinants ofaccess to healthcare in Ukraine, on the evolution of HIV activism and civil society organisations in Ukraine, and on the exogenous influences of their access to medicine movement. This informs the following methodological chapter, which presents Political Process Theory as a guiding theoretical framework and reflexive thematic analysis as a methodological tool. Two findings chapters are based on nine interviews of treatment activists actively involved in the Ukrainian access to medicines movement between 20102021. Both chapters (Who Holds the Reins of Power? and From USSR to a ‘new’ Ukraine generated three key findings: 1) The Euromaidan Revolution coincided with a maturing, expert HIV and Hepatitis C civil society that was able to influence key state functions, but this window of opportunity for reform began to close as Zelensky’s government commenced their tenure; 2) Treatment activism continues to be heavily reliant on international donors due to the growing diplomatic relationship between Ukraine and the European Union, and due to the huge financial, political and human capital needed to oppose the pharmaceutical industry; 3) Despite the EU-Ukraine Free Trade Agreement strengthening intellectual property rights, CSOs adeptly navigate the evolving knowledge economy and political system to continue ensuring access to lifesaving treatment. This study, which finished just before the Russian invasion of Ukraine, concludes by underscoring the importance of resource power, retaining political and social influence, and continuing toward a ‘new Ukraine’ to sustain the momentum of the participants’ access to medicines activism.