Running-related injuries (RRIs) insidiously develop from repetitive micro-traumatic loading, eventually exceeding tissue integrity. With fluctuating and cyclic signs and symptoms, clearly identifying when ‘injury’ has occurred is challenging. This challenge has resulted in conflicting and inconsistent foundational RRI epidemiological evidence (i.e., injury rates and risk factors). Without establishing this evidence, injury prevention cannot advance. The fundamental way ‘injury’ has been considered, not reflective of its true developmental nature, is possibly contributing to the unclear evidence, and adapting how RRIs are captured may be required. This may be achieved with a large-scale, prospective study, monitoring multiple potential risk factors, across the entire injury development process. Wearable technologies offer an elegant solution to capturing and analysing the extent of data required. However, several challenges interfere with this approach: understanding ‘injury’ and the RRI development process, ensuring runners’ engagement with technology, and ensuring runners can be recruited and retained in such a study. The overall aim of this thesis is to explore factors important for the development of an extensive surveillance system for RRIs, using a smartphone app and wearable device(s), to target the fundamental aspects of epidemiological research that appear to be limiting RRI prevention. The results of this thesis have been informed by reviewing the literature regarding defining and measuring RRI severity, and capturing qualitative data from runners to understand their lived experience of injury, their perceptions of wearable technologies for preventing injuries, and their willingness to participate in research. Inconsistent approaches, not reflective of the RRI development process experienced by runners, have been employed to capture RRIs to date. An alternative approach, ensuring lower severity injuries are recognised, is needed to better establish the foundational evidence necessary to advance RRI prevention. Runners appear willing to engage with wearable technologies and to adhere with research requirements to aid the advancement of RRI prevention.