Nurses and health and social care professionals (HSCPs) are integral to multidisciplinary cancer care and are well-positioned to engage in research that enhances patient outcomes. However, unlike medical professionals, non-medical clinicians often face substantial barriers to research engagement, including limited institutional support, time constraints, and lack of research training and mentorship. Aim: To explore the barriers and enablers to research activity among nurses and HSCPs working in clinical cancer care settings in Ireland.