This paper explores methodologies, criteria, and frameworks utilized in safety evaluation within multimodal transportations. However, existing approaches to safety assessment have drawbacks when applied to complex systems, such as multimodal transportation. This includes issues, such as achieving local optimum, managing safety without direct infrastructure ownership, and unifying safety estimates across multiple modes of transport. The safety of these systems relies on both objective conditions and subjective factors aimed at preserving integrity and functionality. Therefore, there’s a need for modeling safety assessments specifically tailored to multimodal freight transportation. This research utilizes mathematical modeling methods to develop an approach for assessing safety, addressing shortcomings of previous studies. The proposed method was applied to an existing multimodal transportation system, demonstrating its potential in evaluating safety levels and optimizing transportation routes.