Article

Smith, Helen ORCID: 0000-0003-4861-0708, Grant, Sharon, Meleady, Paula ORCID: 0000-0001-5306-310X, Henry, Michael, O'Gorman, Donal ORCID: 0000-0002-8228-1488 and Clynes, Martin ORCID: 0000-0002-3093-8185 (2022) Yeast mannan-rich fraction modulates endogenous reactive oxygen species generation and antibiotic sensitivity in resistant E. coli. International Journal of Molecular Sciences, 24 (1). ISSN 1661-6596

Noorani, Sara, Nelson, Shannon R. ORCID: 0000-0003-3014-6679, Conlon, Neil T. ORCID: 0000-0001-5921-7114, Meiller, Justine, Shcheglova, Ekaterina ORCID: 0000-0003-3163-9782, Usai, Alice ORCID: 0000-0003-0226-837X, Stoof, Jojanneke ORCID: 0000-0002-8331-1597, Palanga, Letizia ORCID: 0000-0002-8331-1597, O'Neill, Fiona, Roche, Sandra ORCID: 0000-0002-4363-4607, Cotter, Maura B., Swan, Niall and Walsh, Naomi ORCID: 0000-0002-2178-3564 (2022) Pancreatic cancer 3D cell line organoids (CLOs) maintain the phenotypic characteristics of organoids and accurately reflect the cellular architecture and heterogeneity In vivo. Organoids, 1 (2). pp. 168-183. ISSN 2674-1172

Wallace, Robert G. ORCID: 0000-0002-1450-0634, Rochfort, Keith D. ORCID: 0000-0003-1198-5952, Barabas, Peter ORCID: 0000-0002-8166-3476, Curtis, Timothy M., Uehara, Hironori ORCID: 0000-0001-6133-4918, Ambati, Balamurali and Cummins, Phil (2021) COMP-Ang1: therapeutic potential of an engineered Angiopoietin-1 variant. Vascular Pharmacology, 141 . ISSN 1537-1891

Palanga, Letizia, Goldrick, Caoimhe, Tang, Bobby, Mealy, Grace, Crown, John, Horgan, Noel, Kennedy, Susan and Walsh, Naomi ORCID: 0000-0002-2178-3564 (2021) Hindsight: review of preclinical disease models for the development of new treatments for uveal melanoma. Journal of Cancer, 12 (15). pp. 4672-4685. ISSN 1837-9664

Forde, Hannah ORCID: 0000-0001-7447-7264, Harper, Emma, Rochfort, Keith D. ORCID: 0000-0003-1198-5952, Wallace, Robert G. ORCID: 0000-0002-1450-0634, Davenport, Colin ORCID: 0000-0001-6854-6147, Smith, Diarmuid and Cummins, Phil (2020) TRAIL inhibits oxidative stress in human aortic endothelial cells exposed to pro-inflammatory stimuli. Physiological Reports, 8 (20). ISSN 2051-817X

Collins, Denis ORCID: 0000-0003-1043-6169, Gately, Kathy ORCID: 0000-0002-9616-424X, Hughes, Clare, Edwards, Connla, Davies, Anthony, Madden, Stephen F. ORCID: 0000-0002-0489-4588, O'Byrne, Kenneth J., O'Donovan, Norma ORCID: 0000-0003-1113-3872 and Crown, John ORCID: 0000-0002-3125-7613 (2017) Tyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody dependent cell-mediated cytotoxicity in breast cancer cell lines. Cellular Immunology, 17 (2). pp. 35-42. ISSN 0008-8749

Levingstone, Tanya J. ORCID: 0000-0002-9751-2314, Barron, Niall ORCID: 0000-0003-4602-326X, Ardhaoui, Malika, Benyounis, Khaled ORCID: 0000-0001-6599-4892, Looney, Lisa and Stokes, Joseph ORCID: 0000-0002-6924-1887 (2017) Application of response surface methodology in the design of functionally graded plasma sprayed hydroxyapatite coatings. Surface and Coatings Technology, 313 . pp. 307-318. ISSN 0257-8972

Sheikh, Rizwan, Walsh, Naomi ORCID: 0000-0002-2178-3564, Clynes, Martin ORCID: 0000-0002-3093-8185, O'Connor, Robert ORCID: 0000-0001-5794-6188 and McDermott, Ray (2014) Challenges of drug resistance in the management of pancreatic cancer. Expert Review of Anticancer Therapy, 10 (10). pp. 1647-1661. ISSN 1473-7140

Walsh, Naomi ORCID: 0000-0002-2178-3564, Larkin, Anne-Marie, Swan, Niall, Conlon, Kevin, Dowling, Paul, McDermott, Ray and Clynes, Martin ORCID: 0000-0002-3093-8185 (2011) RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation. Cancer Letters, 306 (2). pp. 180-189. ISSN 0304-3835

Kinsella, Paula (2011) Imatinib and Docetaxel in combination can effectively inhibit glioma invasion in an in vitro 3D invasion assay. Journal of Neuro-Oncology, 101 (2). pp. 189-198. ISSN 0167-594X

Eustace, Alexander J., Mahgoub, Thamir, Tryfonopoulos, Dimitrios, O'Donovan, Norma and Crown, John (2010) Prospects for non-immunological molecular therapeutics in melanoma. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 15 (Jan-Ma). pp. 9-18. ISSN 1107-0625

Walsh, Naomi ORCID: 0000-0002-2178-3564, Kennedy, Susan, Larkin, Anne-Marie, Tryfonopoulos, Dimitrios, Eustace, Alexander J., Mahgoub, Thamir, Conway, Catherine, Oglesby, Irene, Collins, Denis, Ballot, Jo, Ooi, Wei, Gullo, Giuseppe, Clynes, Martin ORCID: 0000-0002-3093-8185, Crown, John and O'Driscoll, Lorraine (2010) Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis. Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis, 102 (7). pp. 1157-1162. ISSN 0007-0920

Walsh, Naomi, Clynes, Martin ORCID: 0000-0002-3093-8185, Crown, John and O'Donovan, Norma (2009) Alterations in integrin expression modulates invasion of pancreatic cancer cells. Journal of Experimental & Clinical Cancer Research, 28 (140). ISSN 1756-9966

McMahon, Joyce, Gallagher, John F. ORCID: 0000-0003-4130-4556, Anderson, Frankie P. and Lough, Alan J. (2009) A structural systematic study of four isomers of difluoro-N-(3-pyridyl)benzamide. Acta Crystallographica Section C, 65 (7). pp. 345-351. ISSN 0108-2701

Walsh, Naomi, Larkin, Anne-Marie, Kennedy, Susan, Connolly, Lisa, Ballot, Jo, Ooi, Wei, Gullo, Giuseppe, Crown, John, Clynes, Martin ORCID: 0000-0002-3093-8185 and O'Driscoll, Lorraine (2009) Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal carcinoma. BMC Urology, 9 (6). ISSN 1471-2490

Stordal, Britta and Davey, Ross (2009) A systematic review of genes involved in the inverse resistance relationship between cisplatin and paclitaxel chemotherapy: role of BRCA1. Current Cancer Drug Targets, 9 (3). pp. 354-365. ISSN 1568-0096

Amberger-Murphy, Verena (2009) Hypoxia helps glioma to fight therapy. Current Cancer Drug Targets, 9 (3). pp. 381-390. ISSN 1568-0096

Walsh, Naomi, O'Donovan, Norma, Kennedy, Susan, Henry, Michael, Meleady, Paula ORCID: 0000-0001-5306-310X, Clynes, Martin ORCID: 0000-0002-3093-8185 and Dowling, Paul (2009) Identification of pancreatic cancer invasion-related proteins by proteomic analysis. Proteome Science, 7 (3). ISSN 1477-5956

Stordal, Britta and Davey, Ross (2009) ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair. Cancer Chemotherapy and Pharmacology, 63 (4). pp. 661-672. ISSN 1432-0843

Walsh, Naomi, Dowling, Paul ORCID: 0000-0002-9290-9267, O'Donovan, Norma, Henry, Michael, Meleady, Paula ORCID: 0000-0002-3093-8185 and Clynes, Martin ORCID: 0000-0002-3093-8185 (2008) Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells. Journal of Proteomics, 71 (5). pp. 561-571. ISSN 1874-3919

Gallagher, John F. ORCID: 0000-0003-4130-4556, McMahon, Joyce, Anderson, Frankie P. and Lough, Alan J. (2008) 2,3-Difluoro-N-(2-pyridyl)benzamide. Acta Crystallographica Section E, 64 (12). ISSN 1600-5368

McMahon, Joyce, Anderson, Frankie P., Gallagher, John F. ORCID: 0000-0003-4130-4556 and Lough, Alan J. (2008) A structural systematic study of three isomers of difluoro-N-(4-pyridyl)benzamide. Acta Crystallographica Section C, 64 (9). pp. 493-497. ISSN 0108-2701

Breen, Laura, Murphy, Lisa, Keenan, Joanne and Clynes, Martin (2008) Development of taxane resistance in a panel of human lung cancer cell lines. Toxicology In Vitro, 22 (5). pp. 1234-1241. ISSN 0887-2333

Hennessy, Erica and O'Driscoll, Lorraine (2008) Molecular medicine of microRNAs: structure, function and implications for diabetes. Expert Reviews in Molecular Medicine, 10 (24). ISSN 1462-3994

Kerr, Gráinne, Ruskin, Heather J. ORCID: 0000-0001-7101-2242, Crane, Martin ORCID: 0000-0001-7598-3126 and Doolan, Padraig (2008) Techniques for clustering gene expression data. Computers in Biology and Medicine, 38 (3). pp. 283-293. ISSN 0010-4825

Stordal, Britta, Pavlakis, Nick and Davey, Ross (2007) A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship. Cancer Treatment Reviews, 33 (8). pp. 688-703. ISSN 0305-7372

Stordal, Britta and Davey, Mary W. (2007) Understanding cisplatin resistance using cellular models. IUBMB Life, 59 (11). pp. 696-699. ISSN 1521-6543

Stordal, Britta, Pavlakis, Nick and Davey, Ross (2007) Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review. Cancer Treatment Reviews, 33 (4). pp. 347-357. ISSN 0305-7372

Amberger-Murphy, Verena (2007) From the bedside to the lab. Cancer Professional, Winter .

Ní Mhurchú, Jenny and Foley, Greg ORCID: 0000-0002-2284-4218 (2006) Dead-end filtration of yeast suspensions: correlating specific resistance and flux data using artificial neural networks. Journal of Membrane Science, 281 (1-2). pp. 325-333. ISSN 0376-7388

Stordal, Britta, Davey, Mary W. and Davey, Ross (2006) Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells. Cancer Chemotherapy and Pharmacology, 58 (2). pp. 256-265. ISSN 0344-5704

Gallagher, John F. ORCID: 0000-0003-4130-4556, Kelly, Paula N., Kenny, Peter T.M. and Lough, Alan J. (2003) Intermolecular interactions in N-(ferrocenylmethyl)anthracene-9-carboxamide. Acta Crystallographica Section C, 59 (12). pp. 552-554. ISSN 0108-2701

Amberger-Murphy, Verena (2003) Editorial: Glioma invasion: mechanism, modulation and future possibilities. Acta Neurochirurgica, 145 (8). pp. 613-614. ISSN 0942-0940

Thesis

Taylor-Jade, Allen Coyle (2024) Multi-drug therapies, their pharmacodynamic interactions and the role of microRNAs in pancreatic cancer models. PhD thesis, Dublin City University.

Berry, Peter (2023) An investigation into approaches and pathways relevant to cellular flocculation in CHO cells. PhD thesis, Dublin City University.

Meiller-Fay, Justine (2023) Studies on generation and characterisation of monoclonal antibodies. Master of Science thesis, Dublin City University.

Coyle, Aleen (2022) The role of selenium in mutagenesis using an in vitro human mutation model. PhD thesis, Dublin City University.

Alarcon Miguez, Antonio ORCID: 0000-0002-2560-5124 (2022) The role of mitochondrial metabolism during recombinant protein production in CHO cells. PhD thesis, Dublin City University.

Nelson, Shannon R. ORCID: 0000-0003-3014-6679 (2022) Novel organoid models for the functional validation of pancreatic cancer genomic variants. PhD thesis, Dublin City University.

O'Reilly, Debbie ORCID: 0000-0001-9405-7961 (2021) Altered calcium signalling in prostate cancer facilitates progression to castrate resistance. PhD thesis, Dublin City University.

Bryan, Laura ORCID: 0000-0002-9422-2338 (2021) Investigating phenotype variability between industrially relevant Chinese hamster ovary (CHO) clonally derived cell lines. PhD thesis, Dublin City University.

Noone, John (2021) The effects of physical inactivity on skeletal muscle metabolic function. PhD thesis, Dublin City University.

O'Doherty, Charles ORCID: 0000-0002-0250-9041 (2020) Cellular and molecular impacts of copper exposure in parental and resistant human intestinal Caco-2 cells. PhD thesis, Dublin City University.

Valdés-Bango Curell, Ricardo (2020) MicroRNAs as metabolic sensors and engineering tools in CHO cells. PhD thesis, Dublin City University.

Kaushik, Prashant (2020) Profiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells. Master of Laws thesis, Dublin City University.

Motheramgari, Krishna C. ORCID: 0000-0003-2499-2713 (2020) Profiling the landscape of long non- coding RNAs in the Chinese hamster ovary cell transcriptome. PhD thesis, Dublin City University.

Capella Roca, Berta (2020) Investigating media supplements to enhance Chinese Hamster ovary cell culture. PhD thesis, Dublin City University.

McPartlin, Daniel (2019) Development of recombinant antibody fragments for toxin and microbial contaminant detection and investigations of microcystin and azaspiracid toxicity. PhD thesis, Dublin City University.

Monger, Craig (2019) Integrated multiomic characterisation of the CHO cell transcriptome and translatome using next generation sequencing. PhD thesis, Dublin City University.

Ontiveros Castillo, Karen Guadalupe (2019) Novel heterocyclic functionalised ferrocenyl derivatives as potential anti-cancer agents. PhD thesis, Dublin City University.

Costello, Alan (2019) RNA manipulations to improve recombinant protein production in Chinese hamster ovary cells. PhD thesis, Dublin City University.

Conlon, Neil (2018) Novel mechanisms of HER2-targeted therapy resistance in breast cancer. PhD thesis, Dublin City University.

Moore, Gemma (2017) Investigation into mechanisms of metastasis in breast cancer and pancreatic cancer. PhD thesis, Dublin City University.

Slator, Creina (2017) Mechanistic investigation of developmental copper chemotherapeutics. PhD thesis, Dublin City University.

McCann, Andrew (2016) Identification of membrane associated proteins as potential markers for the DLKP clonal subpopulations. PhD thesis, Dublin City University.

Kelly, Shane (2016) Proteomic characterisation of clonal populations from a humanlung carcinoma cell line. PhD thesis, Dublin City University.

Solanki, Ankur (2016) microRNAs as potential tools for ‘miR’aculous CHO cell phenotypes in Bioprocessing systems. Master of Science thesis, Dublin City University.

Farrell, Amy (2016) Development and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced bioprocessing of therapeutic proteins. PhD thesis, Dublin City University.

Griffith, Alan (2015) An investigation of novel genetic tools for the manipulation of CHO cell phenotypes during recombinant protein production. PhD thesis, Dublin City University.

Howe, Karen (2015) The role of miRNAs in resistance to HER2 targeted therapies. PhD thesis, Dublin City University.

Gaule, Patricia (2015) c-Met/HGF in triple negative breast cancer. PhD thesis, Dublin City University.

Hayes, Catriona Ann (2015) Intrinsic and extrinsic factors affecting proteasome inhibitor resistance in multiple myeloma. PhD thesis, Dublin City University.

Kelly, Paul S. (2014) Enhancing CHO cell productivity through the stable depletion of microRNA-23. PhD thesis, Dublin City University.

Joyce, Helena (2014) Molecular mechanisms of drug resistance and invasion in a human lung carcinoma cell line. PhD thesis, Dublin City University.

Murphy, James (2014) Biological evaluation of N-Ferrocenyl amino acid and dipeptide ester derivatives as potential anti-cancer agents and investigation into their mode of action in preparation for in vivo evaluation. Master of Science thesis, Dublin City University.

Binti Wan Mohd Noor, Wan Syaidatul Aqma (2013) An investigation of the phenotypic and genotypic changes in Pseudomonas putida CP1 following substrate-dependent autoaggregation. PhD thesis, Dublin City University.

Tryfonopoulos, Dimitrios (2013) Novel targeted agents in Her-2 positive and triple negative breast cancer. Master of Science thesis, Dublin City University.

McDermott, Martina (2012) Mechanisms of resistance to lapatinib in HER2 positive breast cancer. PhD thesis, Dublin City University.

Long, Shelly (2012) Opioids as enantioselective organocatalysts. PhD thesis, Dublin City University.

Fox, Deirdre (2012) Development and application of novel approaches to quantitate therapeutic drugs in human blood. PhD thesis, Dublin City University.

Rajpal, Rajesh (2012) Investigating biomarkers in clinical samples that are predictive of response in multiple myeloma. PhD thesis, Dublin City University.

Hennessy, Erica (2012) Investigation of pancreatic beta cell differentiation and function, and global profiling analysis of diabetes serum for the identification of disease biomarkers. PhD thesis, Dublin City University.

Reddy Katikireddy, Kishore (2012) Primary culture of human limbal-corneal epithelial cells under different conditions. PhD thesis, Dublin City University.

Canning, Daniel (2011) Chiral alkaloid derivatives: Synthesis and medicinal chemistry applications. PhD thesis, Dublin City University.

O'Sullivan, Dermot (2011) Development of monoclonal antibodies for the identification of novel invasion associated targets in human cancer. PhD thesis, Dublin City University.

Roche, Sandra (2011) Development and application of novel analytical methods for molecularly targeted cancer therapeutics. PhD thesis, Dublin City University.

Kinsella, Paula (2011) The Investigation of Targets for Therapy in Brain Tumours. PhD thesis, Dublin City University.

Corkery, Brendan Martin (2010) Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer. PhD thesis, Dublin City University.

Eustace, Alexander J. (2010) Investigation of response and resistance to dasatinib in melanoma cell lines. PhD thesis, Dublin City University.

Dunne, Gráinne (2010) Characterisation and modulation of drug resistance in lung cancer cell lines. Master of Science thesis, Dublin City University.

Mehta, Jai Prakash (2010) Gene expression analysis in breast cancer. PhD thesis, Dublin City University.

Devery, Aoife (2010) Pharmacological modulation and manipulation of cancer drug resistance. PhD thesis, Dublin City University.

Maurya, Priyanka (2009) Identification of proteins associated with cancerous and invasive phenotypes of breast and melanoma cells using proteomic approaches. PhD thesis, Dublin City University.

Kumar, Niraj (2009) Investigation of the molecular mechanisms regulating growth and recombinant protein productivity in suspension-adapted CHO-K1 cells. PhD thesis, Dublin City University.

Kowalska, Ewa (2009) Chiral macrocycles based on the morphine scaffold. PhD thesis, Dublin City University.

Rani, Sweta (2009) Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes. PhD thesis, Dublin City University.

Browne, Brigid (2009) The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer. PhD thesis, Dublin City University.

Ní Mhurchú, Jenny (2008) Dead-end and crossflow microfiltration of yeast and bentonite suspensions: experimental and modelling studies incorporating the use of artificial neural networks. PhD thesis, Dublin City University.

Moran, Brian W. (2008) The synthesis, structural characterization and biological evaluation of potential chemotherapeutic agents. PhD thesis, Dublin City University.

Ferguson, Damien (2008) A study of clinical strains of Pseudomonas Aeruginosa and the investigation of antibiotic resistance mechanisms in the multidrug resistant strain PA13. PhD thesis, Dublin City University.

Conway, Catherine (2008) Development and validation of software solutions to eliminate bottlenecks in the application of high-throughput quantitative immunohistochemistry. PhD thesis, Dublin City University.

Collins, Denis (2008) Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines. PhD thesis, Dublin City University.

Walsh, Naomi (2008) Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma. PhD thesis, Dublin City University.

Redmond, Aisling M. (2007) Investigation of the anti-proliferative and anti-invasive properties of conjugated linoleic acid and novel 5-fluorouracil derivatives including enzyme-activated prodrugs. PhD thesis, Dublin City University.

Henry, Michael (2007) Analysis of the effects of BrdU on DLKP human lung cancer cells by two-dimensional difference gel electrophoresis and mass spectrometry. Master of Science thesis, Dublin City University.

Power, Brendan (2006) Alterations in mRNA and protein profiles in eIF4E-transfected human lung carcinoma cells. PhD thesis, Dublin City University.

Martinez, Vanesa (2006) Drug metabolism and chemotherapy resistance. PhD thesis, Dublin City University.

Pierce, Aisling (2006) Investigation into the molecular mechanisms underlying invasion in the lung carcinoma cell line DLKP and it's chemotherapeutic drug resistant variants. PhD thesis, Dublin City University.

Murphy, Lisa (2006) The detection of potential drug resistance markers using proteomic technologies. PhD thesis, Dublin City University.

Conference or Workshop Item

Alley, Steven, Gallagher, John F. ORCID: 0000-0003-4130-4556, Hooper, Vincent M., Kenny, Peter T.M. and Lough, Alan J. (2005) Synthesis and characterisation of novel ferrocenyl thienyl and thiazolyl systems. In: ACA meeting, 17-22 Jul 2005, Chicago, USA.

Book Section

Stordal, Britta and Davey, Ross (2009) Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest. In: Bonetti, Andrea, Leone, Roberto, Muggia, Franco and Howell, Stephen, (eds.) Platinum and other heavy metal compounds in cancer chemotherapy. Cancer drug discovery and development . Humana Press, pp. 171-176. ISBN 978-1-60327-459-3

Stordal, Britta, Pavlakis, Nick and Davey, Ross (2009) Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy. In: Bonetti, Andrea, Leone, Roberto, Muggia, Franco and Howell, Stephen, (eds.) Platinum and other heavy metal compounds in cance chemotherapy. Cancer drug discovery and development . Humana Press. ISBN 978-1-60327-459-3