Development of enhanced performance luminescence-based optical sensor systems for single-analyte and multii-analyte applications
Moore, John P. (2010) Development of enhanced performance luminescence-based optical sensor systems for single-analyte and multii-analyte applications. PhD thesis, Dublin City University.
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Luminescence-based sensors are widely used and are the subject of considerable
attention from both a research and a commercial perspective. This work details
the development of enhanced-performance luminescence-based sensor systems.
Development eorts have focussed on three areas: instrumentation electronics, en-
hanced luminescence capture-based optical platforms, and multi-parameter sens-
ing using numerical techniques.
Three instrumentation electronics systems were developed using a progressive
design process that culminated in the development of a DSP-based system which
is capable of multi-frequency operation and can be used to obtain intensity, phase
or ratiometric-intensity measurements.
When a luminophore is placed close to a dielectric interface it exhibits an
anisotropic emission prole. An optical probe that exploits this phenomenon
to achieve enhanced luminescence capture was designed previously, however, it
suered from a number of shortcomings. A range of design improvements were
developed and implemented which addressed a number of robustness and reliabil-
ity related issues and which facilitated ratiometric mode operation. In addition,
an enhanced capture element that was optimised for general sensing as opposed to
bio-sensing applications was designed using a combined ray tracing/optimisation
The detection of multiple parameters using a single luminescent sensor ele-
ment is desirable in many applications. A multi-parameter technique was devel-
oped that achieves this through the use of numerical techniques. This approach
addresses a number of limitations that are associated with alternative techniques.
A key part of this work was the development of sensor systems for a number of
specic applications. Sensor systems were developed for the following: real-time
measurement of oxygen concentration in breath, measurement of dissolved oxygen
and dissolved carbon dioxide, and the simultaneous measurement of oxygen and
temperature using a single sensor element.
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