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Exploitation of siderophores for the speciation of iron

Cooke, Colm and Keogh, Damien and Thompson, Roisin and Clarke, Paul A. and O'Connor, Brendan and O'Connell, Michael (2011) Exploitation of siderophores for the speciation of iron. In: Research Review Day 2011, 15 Jun 2011, DCU, Dublin, Ireland.

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Iron is essential for life. It acts as an electron donor/acceptor in metabolic processes facilitated by its variable valency. Although vital, it is toxic at high levels due to Fe2+ oxidation. Iron toxicity is a concern as it can affect growth and product yields in animal cell culture. Siderophores are high affinity Fe3+ chelators produced by microorganisms. This affinity gives them the potential to be used as a basis in platforms to detect and speciate iron in industrial cell culture. Rhizobactin 1021 is of interest due to its decanoic acid “tail” that is not involved in chelation which makes it an ideal target for immobilisation.

Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Uncontrolled Keywords:Iron toxicity; Siderophores
Subjects:Biological Sciences > Microbiology
Biological Sciences > Biochemistry
Biological Sciences > Molecular biology
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
Research Initiatives and Centres > Irish Separation Science Cluster (ISSC)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland
ID Code:17770
Deposited On:08 Feb 2013 11:50 by Brendan O'Connor. Last Modified 15 Feb 2017 16:58

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