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Lectin based glycoprotein analysis

Thompson, Roisin and Clarke, Paul A. and Goel, Alok and O'Connell, Michael and O'Connor, Brendan (2008) Lectin based glycoprotein analysis. In: Glycosciences Ireland, 12 Dec 2008, NUIG, Galway, Ireland.

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Abstract

Many of the biopharmaceutical therapeutics entering the market and currently in clinical trails are recombinant glycoprotein molecules, the glycan moieties of which have a significant impact on efficacy and immunogenicity. The cell culture techniques required to produce these glycoproteins often result in products that are heterogeneous with respect to glycan content. This inconsistency ultimately leads to increased production costs and restricts patient accessibility to these therapeutics. To overcome these difficulties novel analytical platforms facilitating rapid in-process monitoring and product quality control are essential. Work undertaken within the Centre for Bioanalytical Sciences (CBAS) seeks to exploit the microbial world as a source of novel biorecognition elements to produce such platforms.

Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:biopharmaceutical therapeutics
Subjects:Biological Sciences > Biotechnology
Biological Sciences > Microbiology
Biological Sciences > Biochemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
Research Initiatives and Centres > Centre for Bioanalytical Science (CBAS)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Enterprise Ireland, IDA
ID Code:17785
Deposited On:11 Feb 2013 14:35 by Brendan O'Connor. Last Modified 15 Feb 2017 16:59

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