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Cloning of hemagglutinin (HA) protein of influenza A virus - Potential for sialic acid linkage discrimination

Szczepaniak, Jakub and O'Connor, Brendan (2007) Cloning of hemagglutinin (HA) protein of influenza A virus - Potential for sialic acid linkage discrimination. In: Centre for BioAnalytical Sciences meeting 2007, 6 Oct 2007, DCU, Dublin, Ireland.

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Abstract

The initial step in infection of a cell by influenza A virus is the attachment of a virus particle to the target cell. This is accomplished by interaction of a glycoprotein, hemagglutinin (HA), found on the surface of the viral lipid membrane with cell-surface oligosaccharides containing sialic acids. All influenza virus attachment requires terminal sialic acid residues and two major linkages between sialic acid (Neu5Ac) and the penultimate galactose (Gal) residues of carbohydrate side chains are found in nature, Neu5Ac(α2,3)-Gal and Neu5Ac(α2,6)-Gal. The HA’s of different subtypes of influenza A virus exhibit different recognition specificities for these linkages and these linkage specificities have been correlated with host range specificity. The ability of the HA protein to differentiate sialic acid linkages makes it an interesting candidate for use in the characterization of glycoprotein's potentially facilitating the discrimination of alternate glycoforms of biopharmaceutical therapeutics and their subsequent purification.

Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Influenza virus;
Subjects:Biological Sciences > Biotechnology
Biological Sciences > Microbiology
Biological Sciences > Biochemistry
Biological Sciences > Molecular biology
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
Research Initiatives and Centres > Centre for Bioanalytical Science (CBAS)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Enterprise Ireland
ID Code:17787
Deposited On:11 Feb 2013 14:25 by Brendan O'Connor. Last Modified 17 Oct 2016 10:35

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