The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions
Loughran, Noeleen B., O'Connor, Brendan, Ó Fágáin, Ciarán and O'Connell, Mary J.
(2008)
The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions.
BMC Evolutionary Biology, 8
.
pp. 101-111.
ISSN 1471-2148
The mammalian heme peroxidases (MHPs) are a medically important group of enzymes. Included in this group are myeloperoxidase, eosinophil peroxidase, lactoperoxidase, and thyroid peroxidase. These enzymes are associated with such diverse diseases as asthma, Alzheimer’s disease and inflammatory vascular disease. Despite much effort to elucidate a clearer understanding of the function of the 4 major groups of this multigene family, we still do not have a clear understanding of their relationships to each other.