Synthesis and characterisation of novel ferrocenyl thienyl and thiazolyl systems
Alley, Steven and Gallagher, John F. and Hooper, Vincent M. and Kenny, Peter T.M. and Lough, Alan J. (2005) Synthesis and characterisation of novel ferrocenyl thienyl and thiazolyl systems. In: ACA meeting, 17-22 Jul 2005, Chicago, USA.
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Ferrocenyl derivatives are currently under investigation by our group and several series containing both amidothienyl and amidothiazolyl systems have been synthesised and characterised. The incorporation of thienyl/thiazolyl groups into a ferrocenyl- or ferrocenylphenyl system greatly enhances the number of potential donor atoms for coordination with metal fragments e.g. PtII, PdII with a view to platinum anti-cancer studies and/or interaction with guest molecules through suitable hydrogen bonding interactions.
In nature, thiazole has been found to be vital in certain natural products: examples include the antibiotic bacitracin and the siderophore yersiniabactin. In therapeutic studies the antitumour compound epothilone A and myxothiazole (inhibitor) have been extensively studied.
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