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Synthesis and characterisation of novel ferrocenyl thienyl and thiazolyl systems

Alley, Steven and Gallagher, John F. and Hooper, Vincent M. and Kenny, Peter T.M. and Lough, Alan J. (2005) Synthesis and characterisation of novel ferrocenyl thienyl and thiazolyl systems. In: ACA meeting, 17-22 Jul 2005, Chicago, USA.

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Ferrocenyl derivatives are currently under investigation by our group and several series containing both amidothienyl and amidothiazolyl systems have been synthesised and characterised. The incorporation of thienyl/thiazolyl groups into a ferrocenyl- or ferrocenylphenyl system greatly enhances the number of potential donor atoms for coordination with metal fragments e.g. PtII, PdII with a view to platinum anti-cancer studies and/or interaction with guest molecules through suitable hydrogen bonding interactions. In nature, thiazole has been found to be vital in certain natural products: examples include the antibiotic bacitracin and the siderophore yersiniabactin. In therapeutic studies the antitumour compound epothilone A and myxothiazole (inhibitor) have been extensively studied.

Item Type:Conference or Workshop Item (Poster)
Event Type:Conference
Additional Information:Related structures of interest...
Uncontrolled Keywords:Ferrocenyl derivatives
Subjects:Physical Sciences > Inorganic chemistry
Physical Sciences > Chemistry
Physical Sciences > Crystallography
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > National Institute for Cellular Biotechnology (NICB)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:PRTLI-3 (NICB)
ID Code:17915
Deposited On:28 Mar 2013 13:24 by John Gallagher. Last Modified 28 Mar 2013 13:26

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