Biopharmaceutical analysis - an investigation of the pharmacokinetic interaction between xipamide and triamterene when administered alone or in fixed combination
Caffrey, Edward
(1988)
Biopharmaceutical analysis - an investigation of the pharmacokinetic interaction between xipamide and triamterene when administered alone or in fixed combination.
Master of Science thesis, Dublin City University.
A double blind placebo controlled, 4-way crossover
study was carried out to investigate the
pharmacokinetics of single oral doses of xipamide
(lOmg), triamterene (30mg) and Trirexan <10mg xipamide +
30mg triamterene) in a group of 12 healthy male
volunteers. HPLC assays were developed for the
measurement of both drugs in plasma. Plasma levels of
xipamide and triamterene were measured using these
validated HPLC methods. The individual plasma level
data are presented as tables and the mean plasma levels
are presented graphically. Plasma xipamide levels
measured over a 24 hour period after dosing with
xipamide alone and in a fixed combination as Trirexan
were analysed using the JANA curve stripping program.
The estimates of the pharmacokinetic parameters thus
obtained were then used in curve fitting analysis using
an IBM-PC compatible version of NONLIIT 84. Plasma
triamterene levels after dosing with triamterene and
Trirexan were likewise analysed.