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Development of hierarchical magnetic nanocomposite materials for biomedical applications

Clarke, Sarah (2013) Development of hierarchical magnetic nanocomposite materials for biomedical applications. PhD thesis, Dublin City University.

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Abstract

Magnetic nanocomposites and nanoparticle assemblies have gained significant interest for biomedical applications including MRI, hyperthermia and targeted drug delivery. Their efficacy depends on colloidal stability, optimal magnetic properties and appropriate size and surface chemistry for good biodistribution. The first part of this thesis focuses on the preparation of sub 20 nm magnetic nanoparticles (IONP) and the modification of their surface charge for subsequent encapsulation or adsorption to the polymer poly n-butyl cyanoacrylate (PACA) to produce IONP dilute assemblies. In addition to this, IONP-dense assemblies were prepared using established methods, and the effect of IONP density on the magnetic resonance properties of the assemblies was assessed. It was found that the NMR response was very sensitive to the IONP density and also to the structure of the assembly. This suggests potential routes to novel materials with tunable MRI properties. The second part of the thesis focuses on the assembly of IONP into dense assemblies (or clusters) in organic media using a novel in situ assembly technique based on reducing surfactant coverage. Particular attention was paid to the kinetics of the assembly process and the effect of adding surfactants and/or gold nanoparticles to the metastable IONP assemblies was also studied.

Item Type:Thesis (PhD)
Date of Award:November 2013
Refereed:No
Supervisor(s):Brougham, Dermot
Uncontrolled Keywords:Magnetic nanocomposites; nanoparticle assemblies; biomedical applications
Subjects:Physical Sciences > Nanotechnology
Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
ID Code:19392
Deposited On:25 Nov 2013 15:02 by Dermot Brougham. Last Modified 25 Nov 2013 15:02

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