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Pharmaceutical impurity assay method development using core-shell stationary phase technology for HPLC and evaluation of stationary and mobile phases for an orthogonally selective SFC impurity assay

Gaffney, Orla (2014) Pharmaceutical impurity assay method development using core-shell stationary phase technology for HPLC and evaluation of stationary and mobile phases for an orthogonally selective SFC impurity assay. Master of Science thesis, Dublin City University.

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Abstract

The demand for faster, greener, more cost effective processes is of great important across all industries including chemical pharmaceutical and petrochemical sectors. As a result the key driver of chromatographic research is addressing these demands. The ultimate goal in liquid chromatography is “The best separation in the shortest time”. While sub 2µm fully porous particle stationary phases have addressing this demand for faster more efficiency separations, a research focus which has recently seen a resurgence has been core-shell particle technologies which offer similar performance to sub 2 µm particles without the added back pressure requirements of sub 2 µm fully porous particles.

Item Type:Thesis (Master of Science)
Date of Award:November 2014
Refereed:No
Supervisor(s):White, Blánaid and Connolly, Damian and O Gorman, Mary
Uncontrolled Keywords:Chromatography
Subjects:Physical Sciences > Analytical chemistry
Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
Funders:IRC, Pfizer PDC
ID Code:20172
Deposited On:27 Nov 2014 13:42 by Blanaid White. Last Modified 26 Apr 2017 16:20

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