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Estimation of toxic elements in the samples of different cigarettes and their impact on human health of Irish hypertensive consumers

Afridi, Hassan Imran and Gul Kazi, Tasneem and Naz Talpur, Farah and Brabazon, Dermot and Naher, Sumsun (2013) Estimation of toxic elements in the samples of different cigarettes and their impact on human health of Irish hypertensive consumers. Clinica Chimica Acta, 426 . pp. 51-57. ISSN 0009-8981

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Abstract

Background: Cigarette smoking interferes with the metal homeostasis of the human body, which plays a crucial role for maintaining the health. A significant flux of heavy metals, among other toxins, reaches the lungs through smoking. In the present study, the relationship between toxic element (TE) exposure via cigarette smoking and hypertension incidence in population living in Dublin, Ireland is investigated. Methods: The different brands of cigarette (filler tobacco, filter and ash) consumed by the studied population were analyzed for cadmium (Cd), nickel (Ni), and lead (Pb). The concentrations of TEs in biological samples and different components of cigarette were measured by inductively coupled plasma atomic emission spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked using certified reference materials. Results: The filler tobacco of different branded cigarettes contains Cd, Ni and Pb concentrations in the ranges of 1.73-2.02, 0.715-1.52 and 0378-1.16 pg/cigarette, respectively. The results of this study showed that the mean values of Cd, Ni and Pb were significantly higher in scalp hair and blood samples of hypertensive patients in relation to healthy controls, while the difference was significant in the case of smoker patients (p < 0.001). The levels of all the three TEs were 2-3 folds higher in scalp hair and blood samples of non-hypertensive smoker subjects as compared to nonsmoker controls. Conclusion: The high exposure of toxic metals as a result of cigarette smoking may be synergistic with risk factors associated with hypertension.

Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:Blood; Cigarette smokers; Different brands of cigarette; Inductive coupled plasma atomic emission spectrophotometer; Scalp hair; Toxic elements
Subjects:Physical Sciences > Analytical chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Publisher:Elsevier
Official URL:http://dx.doi.org/10.1016/j.cca.2013.08.023
Copyright Information:© 2013 Elsevier
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:20533
Deposited On:27 Mar 2015 14:46 by Fran Callaghan. Last Modified 27 Mar 2015 14:46

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