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Development and application of a wearable device for real time potentiometric determination of electrolytes in sweat

Glennon, Thomas (2017) Development and application of a wearable device for real time potentiometric determination of electrolytes in sweat. Master of Science thesis, Dublin City University.

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Abstract

The most common methods of biomedical diagnosis are blood-based and therefore require invasive methods for acquiring a sample causing trauma and presenting a risk of infection. This has led to the development of sensors targeting minimally invasive bio-fluids such as interstitial fluid and non-invasive bio-fluids including saliva and sweat. The monitoring of sweat in electrolytes, for example, has a number of applications including determining the efficacy of drugs on the chloride and sodium levels in cystic fibrosis patients as well as the monitoring of hydration levels in athletes to detect non-symptomatic overhydration, dehydration and fatigue. This work presents the development of a platform for harvesting and analysing the sodium content of sweat in real time. In chapter 2 miniaturised solid-state sodium-selective and reference electrodes are developed, characterized and optimised. In chapter 3 these sensors are then incorporated into a custom designed sampling and fluidic system allowing passive transfer of the sweat from a point of contact on the skin to a fluidic channel across the electrodes for analysis before transport to a sampling reservoir. Chapter 4 presents the integration and real-time on-body trials of the sensing and fluidic components with a custom-designed electronic circuit board and lithium battery. Two platforms were developed, a ‘watch’ type format for wrist based analysis and a ‘pod’ format, arranged horizontally for adaptable monitoring in various regions of the body. The devices can be easily disassembled to replace the electrodes and the high capacity adsorbent material. The storage sweat is available for subsequent measurement of the total volume of sweat harvested and the average concentration of sodium over the period of use. Results obtained during trials over a period of up to 60 minutes controlled exercise are consistent with previously published data, showing a gradual increase of the sodium concentration in the sweat during this period.

Item Type:Thesis (Master of Science)
Date of Award:November 2017
Refereed:No
Supervisor(s):Diamond, Dermot and Ducreé, Jens
Subjects:Physical Sciences > Analytical chemistry
Biological Sciences > Microfluidics
Medical Sciences > Performance
Physical Sciences > Electrochemistry
Biological Sciences > Biosensors
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > INSIGHT Centre for Data Analytics
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
Funders:Science Foundation Ireland
ID Code:21768
Deposited On:08 Nov 2017 16:28 by Dermot Diamond. Last Modified 08 Nov 2017 16:28

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