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Electrochemistry and application of a novel monosubstituted squarate electron-transfer mediator in a glucose oxidase-doped poly(phenol) sensor

Iwuoha, Emmanuel I. and Williams-Dottin, Avril R. and Hall, Lincoln A. and Morrin, Aoife and Mathebe, Gretta N. and Smyth, Malcolm R. and Killard, Anthony J. (2004) Electrochemistry and application of a novel monosubstituted squarate electron-transfer mediator in a glucose oxidase-doped poly(phenol) sensor. Pure Applied Chemistry, 76 (4). pp. 789-799. ISSN 1365-3075

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Abstract

Electrosynthetic poly(phenol) nanofilms were deposited in situ on platinum electrodes in the presence and absence of glucose oxidase. The synthesis charges and currents of the nonconducting polymer films were recorded at various applied potentials for films grown from 25–100 mM phenol concentrations. Film parameters such as the standard rate constant for film deposition, film thickness, and surface concentration of the poly(phenol) films were evaluated from the cyclic and step voltammograms of the polymerization process. A novel electron-transfer mediator consisting of monosubstituted 4-hydroxycyclobut-3-ene-1,2-dione (squarate) was used as a mediator for Pt/poly(phenol) nano-film/GOx amperometric glucose biosensors. Amperometric responses for 3-diphenylamino-4-hydroxycyclobut-3-ene-1,2- dione (diphenylaminosquarate: E°′ = of +328 mV/Ag-AgCl at pH 7.0)-mediated systems were measured by both steady-state amperometric and cyclic voltammetry. The sensor sensitivity was calculated to be 558 nA cm –2 (µM) –1 .

Item Type:Article (Published)
Refereed:Yes
Additional Information:Plenary lecture presented at the Inaugural Conference for the Southern and Eastern Africa Network of Analytical Chemists (SEANAC), Gaborone, Botswana, 7-10 July 2003
Subjects:Physical Sciences > Analytical chemistry
Physical Sciences > Electrochemistry
Physical Sciences > Chemistry
Biological Sciences > Biosensors
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Initiatives and Centres > National Centre for Sensor Research (NCSR)
Publisher:International Union of Pure and Applied Chemistry
Official URL:http://dx.doi.org/10.1351/pac200476040789
ID Code:55
Deposited On:08 Nov 2006 by DORAS Administrator. Last Modified 30 Jan 2009 12:04

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