Walshe, Alan (2003) Immune responses to Fasciola hepatica infection, and Fasciola hepatica derived antigens. Master of Science thesis, Dublin City University.
Abstract
The aim of this study was to investigate immune responses as a result of infection with the parasitic helminth, Fasciola hepatica. Analysis of IL-4 and Interferon-y cytokines described a predominant type 2 immune response in BALB/c mice infected with metacercana of F hepatica Levels of IL-4 mRNA assessed by reverse transcnption-polymerase chain reaction (RT-PCR) provide the first evidence that the immune response becomes polarised 1 day post infection. We also investigated immune responses to F hepatica derived antigens IL-4 and Interferon-y cytokine production revealed a polarised type 2 response m BALB/c mice immunised with F hepatica excretory/secretory (ES) products. As type 1 immune responses have been associated with protection against infection with F hepatica (Mulcahy et a l , 1998), we established a polarised type 1 immune response in BALB/c mice by immunising with cathepsm L in combination with various adjuvants.
Metadata
| Item Type: | Thesis (Master of Science) |
|---|---|
| Date of Award: | 2003 |
| Refereed: | No |
| Supervisor(s): | O'Neill, Sandra |
| Uncontrolled Keywords: | Fasciola hepatica; Antigen-antibody reactions; Liver flukes; Immune response |
| Subjects: | Biological Sciences > Biotechnology Humanities > Biological Sciences > Biotechnology |
| DCU Faculties and Centres: | DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology |
| Use License: | This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License |
| ID Code: | 18265 |
| Deposited On: | 27 May 2013 13:53 by Celine Campbell . Last Modified 27 May 2013 13:53 |
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