Pharmaceutical impurity assay method development using core-shell stationary phase technology for HPLC and evaluation of stationary and mobile phases for an orthogonally selective SFC impurity assay
Gaffney, Orla
(2014)
Pharmaceutical impurity assay method development using core-shell stationary phase technology for HPLC and evaluation of stationary and mobile phases for an orthogonally selective SFC impurity assay.
Master of Science thesis, Dublin City University.
The demand for faster, greener, more cost effective processes is of great important across all industries including chemical pharmaceutical and petrochemical sectors. As a result the key driver of chromatographic research is addressing these demands. The ultimate goal in liquid chromatography is “The best separation in the shortest time”. While sub 2µm fully porous particle stationary phases have addressing this demand for faster more efficiency separations, a research focus which has recently seen a resurgence has been core-shell particle technologies which offer similar performance to sub 2 µm particles without the added back pressure requirements of
sub 2 µm fully porous particles.
Item Type:
Thesis (Master of Science)
Date of Award:
November 2014
Refereed:
No
Supervisor(s):
White, Blánaid and Connolly, Damian and O'Gorman, Mary