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Permeability of rapid prototyped artificial bone scaffold structures.

Lipowiecki, Marcin, Ryvolova, Marketa, Tottosi, Akos, Kolmer, Niels, Naher, Sumsun orcid logoORCID: 0000-0003-2047-5807, Brennan, Stephen A., Vázquez, Mercedes orcid logoORCID: 0000-0002-9770-5562 and Brabazon, Dermot orcid logoORCID: 0000-0003-3214-6381 (2014) Permeability of rapid prototyped artificial bone scaffold structures. Journal of Biomedical Materials Research Part A, 102 (11). pp. 4127-4135. ISSN 1549-3296

Abstract
In this work, various three-dimensional (3D) scaffolds were produced via microstereolithography (m-SLA) and 3D printing (3DP) techniques. This work demonstrates the advantages and disadvantages of these two different rapid prototyping methods for production of bone scaffolds. Compared to 3DP, SLA provides for smaller feature production with better dimensional resolution and accuracy. The permeability of these structures was evaluated experimentally and via numerical simulation utilizing a newly derived Kozeny– Carman based equation for intrinsic permeability. Both experimental and simulation studies took account of porosity percentage, pore size, and pore geometry. Porosity content was varied from 30% to 70%, pore size from 0.34 mm to 3 mm, and pore geometries of cubic and hexagonal closed packed were examined. Two different fluid viscosity levels of 1 mPas and 3.6 mPas were used. The experimental and theoretical results indicated that permeability increased when larger pore size, increased fluid viscosity, and higher percentage porosity were utilized, with highest to lowest degree of significance following the same order. Higher viscosity was found to result in permeabilities 2.2 to 3.3 times higher than for water. This latter result was found to be independent of pore morphology type. As well as demonstrating method for determining design parameters most beneficial for scaffold structure design, the results also illustrate how the variations in patient’s blood viscosity can be extremely important in allowing for permeability through the bone and scaffold structures.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:Permeability; Synthetic scaffold; Tissue engineering; Trabecular bone; Rapid prototyping
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:Research Institutes and Centres > Irish Separation Science Cluster (ISSC)
Research Institutes and Centres > Advanced Processing Technology Research Centre (APT)
DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Publisher:John Wiley & Sons
Official URL:http://dx.doi.org/10.1002/jbm.a.35084
Copyright Information:© 2014 Wiley. The definitive version is available at www3.interscience.wiley.com
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:20549
Deposited On:02 Apr 2015 10:55 by Fran Callaghan . Last Modified 20 Sep 2018 08:52
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