Sleep apnea is a common condition that seriously degrades sleep quality. Related researches have shown that patients suffering from sleep apnea have higher risks of accidents both at home and at work [1]. In addition, sleep apnea has been associated with an increased risk of cardiovascular related deaths and metabolic conditions, including hypertension, stroke, congestive heart failure, and sudden death [2]. Sleep apnea is estimated to affect 2-4% of middle-aged adults [3]. Up to 80% of these cases are undiagnosed and untreated by the healthcare system [4]. Sleep apnea disease presents also an economical burden on healthcare systems. In this work, the results of clinical trials of evaluating the possibility of using a wearable sensor garment for in-home screening of obstructive sleep apnea and hypoapnea (OSAS) are presented. The garment incorporates ECG, respiration and position signals. The performances of the sensors of the garment were compared to the signal collected during a routine overnight polysomnograph (PSG) in a sleep clinic. The results showed comparable performance of the garment and PSG thus demonstrating the possibility of using the wearable sensor garment as part of an in-home screening system for sleep apnea events.