New cure accelerators for anaerobic adhesives have been designed to offer less harmful alternatives to current industry standard accelerators. Accelerators in current use are comprised of compounds such as acetylphenylhydrazine (APH), diethyl-p- toluidine (DEpT), tetrahydroquinoline (THQ) and their derivatives, all of which can be classified as being acutely toxic or harmful to the user. Further to this, there is no consensus as to their mode of action within the curing of the adhesive and how they affect the radically initiated polymerisation mechanism. Safer alternative cure accelerators have been designed and added insight as to their mechanistic role gained through the conception, synthesis, and screening of “generations” of accelerators and structurally similar compounds for key properties such as anti-microbial toxicity, cytotoxicity, biodegradability, eco-toxicity, and cure activity. With the analysis of each generation, more information was gathered and the structure activity relationship for these properties further elucidated. This greatly aided the design of each succeeding generation of synthetic targets in order to maximise their accelerator activity whilst reducing their risk to the user and the environment. This approach not only yielded new ionic liquid based cure accelerators but also opened up new directions for their future development and design by identifying classes of compounds not previously used for this purpose. These saccharinate, acesulfamate, and phthalimate based compounds have been proven to possess activity equal to current industry benchmarks whilst being of low cytotoxicity and anti-microbial activity. Furthermore, these compounds offer significant room in their scope for derivitisation and development as custom designed cure catalysts.