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Probabilistic models for dissolution of ethylcellulose coated microsphere

Bezbradica, Marija ORCID: 0000-0001-9366-5113, Barat, Ana, Ruskin, Heather J. and Crane, Martin ORCID: 0000-0001-7598-3126 (2010) Probabilistic models for dissolution of ethylcellulose coated microsphere. In: ESM 2010 - European Simulation and Modelling Conference, 25-27 Oct 2010, Hasselt, Belgium. ISBN 978-90-77381-57-1

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Abstract

In the last few decades, a number of probabilistic models for drug delivery have been developed. Of particular interest are those that model controlled release systems to provide targeted dose delivery. Controlled release is achieved by using polymers with different dissolution characteristics. We present here a model based on Monte Carlo and Cellular Automata approaches, for simulating drug release from coated microspheres in the gastro-intestinal tract. Controlled release is obtained using ethylcellulose as the coating polymer. Modelling features, such as the drug and coating dissolution are non-trivial, since material is non-homogenously dispersed and the dissolution exhibits complex behaviour. Important underlying mechanisms of the process, such as erosion, are described here.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Discrete Simulation; Monte Carlo; Cellular Automata; Microspheres; Drug Dissolution
Subjects:Computer Science > Computational complexity
Medical Sciences > Pharmacology
DCU Faculties and Centres:Research Initiatives and Centres > Scientific Computing and Complex Systems Modelling (Sci-Sym)
DCU Faculties and Schools > Faculty of Engineering and Computing > School of Computing
Published in: Proceedings ESM 2010 - European Simulation and Modelling Conference. Proceedings ESM . ESM- Eurosis. ISBN 978-90-77381-57-1
Publisher:ESM- Eurosis
Official URL:https://www.eurosis.org/cms/files/proceedings/ESM/ESM2010contents.pdf
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
ID Code:21698
Deposited On:01 Feb 2017 16:56 by Thomas Murtagh . Last Modified 19 Nov 2021 11:45

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