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Cross-sectional analysis of the prevalence and predictors of statin utilisation in Ireland with a focus on primary prevention of cardiovascular disease

Byrne, Paul, Cullinan, John, Murphy, Catriona orcid logoORCID: 0000-0002-3262-1130 and Smith, Susan M. (2018) Cross-sectional analysis of the prevalence and predictors of statin utilisation in Ireland with a focus on primary prevention of cardiovascular disease. BMJ Open .

Abstract
Objective To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary prevention of cardiovascular disease (CVD). Methods This is a cross-sectional analysis of cardiovascular risk and sociodemographic factors associated with statin utilisation from wave 1 of The Irish Longitudinal Study on Ageing. A hierarchy of indications for statin utilisation, consisting of eight mutually exclusive levels of CVD-related diagnoses, was created. Participants were assigned one level of indication. The prevalence of statin utilisation was calculated. The likelihood that an individual was using a statin was estimated using a multivariable logistic regression model, controlling for cardiovascular risk and sociodemographic factors. Results In this nationally representative sample (n=5618) of community-dwelling participants aged 50 years and over, 1715 (30.5%) were taking statins. Of these, 65.0% (57.3% of men and 72.7% of women) were doing so for the primary prevention of CVD. Thus, almost two-thirds of those taking statins did so for primary prevention and there was a notable difference between women and men in this regard. We also found that statin utilisation was highest among those with a prior history of CVD and was significantly associated with age (compared with the base category 50–64 years; 65–74 years OR 1.38 (95% CI 1.16 to 1.65); 75+ OR 1.33 (95% CI 1.04 to 1.69)), living with a spouse or partner (compared with the base category living alone; OR 1.35 (95% CI 1.10 to 1.65)), polypharmacy (OR 1.74 (95% CI 1.39 to 2.19)) and frequency of general practitioner visits (compared with the base category 0 visits per year; 1–2 visits OR 2.46 (95% CI 1.80 to 3.35); 3–4 visits OR 3.24 (95% CI 2.34 to 4.47); 5–6 visits OR 2.98 (95% CI 2.08 to 4.26); 7+ visitsOR 2.51 (95% CI 1.73 to 3.63)), even after controlling for clinical need. There was no association between using statins and gender, education, income, social class, health insurance status, location or Systematic Coronary Risk Evaluation (SCORE) risk in the multivariable analysis. Conclusion Statin utilisation among those with no history of CVD accounted for almost two-thirds of all statin use, in part reflecting the high proportion of the population with no history of CVD, although utilisation rates were highest among those with a history of CVD.
Metadata
Item Type:Article (Published)
Refereed:Yes
Additional Information:The authors would like to thank TILDA for providing access to the data, in particular Hugh Nolan and Neil O’Leary. In addition, although the data were not used in final analysis, the authors would like to thank Kathleen Bennett and the HSE-PCRS for access. Marie Therese Cooney wrote the code we used for SCORE risk calculation and Ronan Conroy from RCSI assisted in the use of this code. In addition, the authors would also like to thank Daniela Rohde, SPHeRE scholar, for her help.
Subjects:Medical Sciences > Nursing
Mathematics
Medical Sciences > Epidemiology
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Nursing and Human Sciences
Publisher:British Medical Journal
Official URL:http://doi.org/10.1136/bmjopen-2017-018524
Copyright Information:© The Authors 2018
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Health Research Board (grant no. HRB/ICE 2012/7), Atlantic Philanthropies, Department of Health, Irish Life
ID Code:22243
Deposited On:14 Feb 2018 09:51 by Catriona Murphy . Last Modified 20 Nov 2019 09:56
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