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Rethinking on/in-body biochemical sensing strategies to achieve long-term functionality

Diamond, Dermot orcid logoORCID: 0000-0003-2944-4839 (2019) Rethinking on/in-body biochemical sensing strategies to achieve long-term functionality. In: American Chemical Society Fall Conference, 25-29 Aug 2019, San Diego, USA.

Despite huge efforts and investments in biosensor research and development over several decades, and apparently promising developments, implantable devices capable of providing long-term (months, years) continuous monitoring of key molecular disease markers remain far from practical implementation. The reasons for this are many-fold, but the most important relate to fundamental materials challenges associated with biocompatibility, and practical barriers related to checking of system integrity. While the management of many chronic health conditions clearly would improve significantly from advances in continuous long-term monitoring, the management of diabetes is most apparent, due to the scale of the problem, and its huge impact on people, society and our health systems. Today, the state of the art in diabetes patient care is around 10-15 days continuous monitoring via devices that are attached to the body, and monitor glucose in interstitial fluid via a very fine filament that penetrates through the skin to access the sample . Examples include the Abbott Freestyle Libre (https://www.freestylelibre.ie) and the Dexcom G6 Technologies (http://dexcom.eu/). These disruptive developments will drive demand for improved sensor performance, which places an increasing focus on how to dramatically extend the functional lifetime of such biosensors, which in turn will drive new thinking around the fundamental materials challenges of long-term on-body/in-body biosensing and controlled therapeutics (in this case insulin delivery) . In this lecture, I will discuss these and related issues, and speculate on strategies for delivering longer-term sensing and control functions based on the inherent behaviour of materials, rather than conventional approaches. I will also discuss the need to review the sensor related aspects of papers much more rigorously, in order to manage the longer-term negative impact of unrealistic media interpretations.
Item Type:Conference or Workshop Item (Invited Talk)
Event Type:Conference
Subjects:Biological Sciences > Biosensors
Biological Sciences > Microfluidics
Physical Sciences > Analytical chemistry
Physical Sciences > Chemical detectors
Physical Sciences > Electrochemistry
Physical Sciences > Photochemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Institutes and Centres > National Centre for Sensor Research (NCSR)
Research Institutes and Centres > INSIGHT Centre for Data Analytics
Copyright Information:© 2019 The Aurthor
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland, Horizon 2020 Holifab Project, Enterprise Ireland
ID Code:23677
Deposited On:16 Sep 2019 11:04 by Dermot Diamond . Last Modified 16 Sep 2019 11:04

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