Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based on dissolvable film with electrochemical detection, enables accelerated, real-time characterization of ODD devices.
Item Type:
Conference or Workshop Item (Poster)
Event Type:
Conference
Refereed:
Yes
Uncontrolled Keywords:
Lab-on-a-Disc; Oral drug delivery devices; Microcontainers; Event-triggered valves
This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:
Danish National Research Foundation (DNRF122), Villum Fonden (Grant No. 9301) for Intelligent Drug delivery and sensing Using micro-containers and Nanomechanics (IDUN)
ID Code:
23914
Deposited On:
11 Nov 2019 12:08 by
David Kinahan
. Last Modified 04 Feb 2020 14:24