Artificial gut-on-a-disc platform to evaluate PH sensitive coatings of oral drug delivery devices
Thoppe Rajendran, Sriram 
ORCID: 0000-0003-3667-0834, Kamguyan, Khorshid, Kinahan, David J. ORCID: 0000-0003-1968-2016, Hwu, En-Te ORCID: 0000-0002-5971-4978, Nielsen, Line Hagner ORCID: 0000-0002-3789-4816, Zor, Kinga ORCID: 0000-0002-2905-4155 and Boisen, Anja ORCID: 0000-0002-9918-6567
(2019)
Artificial gut-on-a-disc platform to evaluate PH sensitive coatings of oral drug delivery devices.
In: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2019), 27 - 31 Oct 2019, Basel, Switzerland.
ISBN 978-1-7334190-0-0
Abstract
Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based on dissolvable film with electrochemical detection, enables accelerated, real-time characterization of ODD devices.
Metadata
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Event Type: | Conference |
| Refereed: | Yes |
| Uncontrolled Keywords: | Lab-on-a-Disc; Oral drug delivery devices; Microcontainers; Event-triggered valves |
| Subjects: | Engineering > Biomedical engineering |
| DCU Faculties and Centres: | DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering Research Initiatives and Centres > Advanced Processing Technology Research Centre (APTRC) Research Initiatives and Centres > Water Institute |
| Copyright Information: | © 2019 The Authors |
| Use License: | This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License |
| Funders: | Danish National Research Foundation (DNRF122), Villum Fonden (Grant No. 9301) for Intelligent Drug delivery and sensing Using micro-containers and Nanomechanics (IDUN) |
| ID Code: | 23914 |
| Deposited On: | 11 Nov 2019 12:08 by David Kinahan . Last Modified 26 Sep 2023 09:57 |
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