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Electrostatically modulated magnetophoretic transport of functionalised iron-oxide nanoparticles through hydrated networks

Lyons, Stephen, McKiernan, Eoin P., Dee, Garret orcid logoORCID: 0000-0003-3764-6967, Brougham, Dermot F. orcid logoORCID: 0000-0002-1270-8415 and Morrin, Aoife orcid logoORCID: 0000-0002-3031-4794 (2020) Electrostatically modulated magnetophoretic transport of functionalised iron-oxide nanoparticles through hydrated networks. Nanoscale, 19 . pp. 10550-10558. ISSN 2040-3364

Factors that determine magnetophoretic transport of magnetic nanoparticles (MNPs) through hydrated polymer networks under the influence of an external magnetic field gradient were studied. Functionalised iron oxide cores (8.9 nm core diameter) were tracked in real-time as they moved through agarose gels under the influence of an inhomogeneous magnetic field. Terminal magnetophoretic velocities were observed in all cases, these were quantified and found to be highly reproducible and sensitive to the con- ditions. Increasing agarose content reduced magnetophoretic velocity, we attribute this to increasingly tortuous paths through the porous hydrated polymer network and propose a new factor to quantify the tortuosity. The impact of MNP surface functionalisation, charge, network fixed charge content, and ionic strength of the aqueous phase on velocity were studied to separate these effects. For MNPs functionalised with polyethylene glycol (PEG) increasing chain length reduced velocity but the tortuosity extracted, which is a function of the network, was unchanged; validating the approach. For charged citrate- and arginine-functionalised MNPs, magnetophoretic velocities were found to increase for particles with posi- tive and decrease for particles with negative zeta potential. In both cases these effects could be moder- ated by reducing the number of agarose anionic residues and/or increasing the ionic strength of the aqueous phase; conditions under which tortuosity again becomes the critical factor. A model for MNP transport identifying the contributions from the tortuous pore network and from electrostatic effects associated with the pore constrictions is proposed.
Item Type:Article (Published)
Uncontrolled Keywords:Magnetophoresis, iron oxide, hydrogel, tissue mimic
Subjects:Physical Sciences > Chemistry
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences
Research Institutes and Centres > National Centre for Sensor Research (NCSR)
Research Institutes and Centres > INSIGHT Centre for Data Analytics
Publisher:Royal Society of Chemistry
Official URL:http://dx.doi.org/10.1039/d0nr01602k
Copyright Information:© The Royal Society of Chemistry
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:Science Foundation Ireland under Grant Agreement Nos 13/CDA/2155 and 16/IA/4584.
ID Code:25059
Deposited On:05 Oct 2020 16:51 by Aoife Morrin . Last Modified 01 Mar 2021 04:30

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