This paper presents a numerical investigation and assessment of thermal and hydraulic performance of dimpled tubes of varying topologies at constant heat flux of and Reynolds numbers ranging from 2300 to 15,000 The performance of the tubes consisting of conical, spherical and ellipsoidal dimples with equivalent flow volumes were compared using steady state Reynolds Averaged Navier Stokes simulations. The ellipsoidal dimples, in comparison to other dimple shapes, demonstrated large increment in heat transfer rate. The variation in the orientation of the ellipsoidal dimples was examined to further improve thermal and hydraulic performances of the tube. A 45° inclination angle of ellipsoidal dimple, from its major axis, increased the thermo-hydraulic performance by 58.1% and 20.2% in comparison to smooth tube and 0° ellipsoidal dimpled tube, respectively. Furthermore, Large Eddy Simulations (LES) were carried out to investigate the role geometrical assistance to fluid flow and heat transfer enhancement for the 45° and 90° ellipsoidal dimpled tubes. LES results revealed a flow channel of connected zones of wakes which maximized fluid-surface c