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Hydroxyapatite sonosensitisation of ultrasound-triggered, thermally responsive hydrogels: an on-demand delivery system for bone repair applications

Levingstone, Tanya J. orcid logoORCID: 0000-0002-9751-2314, Ali, Badriah, Kearney, Cathal orcid logoORCID: 0000-0002-9514-6517 and Dunne, Nicholas orcid logoORCID: 0000-0003-4649-2410 (2021) Hydroxyapatite sonosensitisation of ultrasound-triggered, thermally responsive hydrogels: an on-demand delivery system for bone repair applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 109 (10). pp. 1622-1633. ISSN 1552-4973

Abstract
While bones have the innate capability to physiologically regenerate, in certain cases regeneration is suboptimal, too slow, or does not occur. Biomaterials-based growth factor delivery systems have shown potential for the treatment of challenging bone defects, however, achieving controlled growth factor release remains a challenge. The objective of this study was to develop a thermally responsive hydrogel for bone regeneration capable of ultrasound-triggered on-demand delivery of therapeutic agents. Furthermore, it was hypothesized that incorporation of hydroxyapatite (HA) into the hydrogel could increase sonosensitization, augmenting ultrasound sensitivity to enable controlled therapeutic release to the target tissue. Alginate thermally responsive P(Alg-g-NIPAAm) hydrogels were fabricated and varying quantities of HA (1, 3, 5, and 7% wt./vol.) incorporated. All hydrogels were highly injectable (maximum injection force below 6.5 N) and rheological characterization demonstrated their ability to gel at body temperature. The study demonstrated the ultrasound-triggered release of sodium fluorescein (NaF), bovine serum albumin (BSA), and bone morphogenetic protein 2 (BMP-2) from the hydrogels. Release rates of BSA and BMP-2 were significantly enhanced in the HA containing hydrogels, confirming for the first time the role of HA as a son sensitizer. Together these results demonstrate the potential of these ultrasound-triggered thermally responsive hydrogels for on-demand delivery of therapeutic agents for bone regeneration.
Metadata
Item Type:Article (Published)
Refereed:Yes
Uncontrolled Keywords:bone; controlled delivery; hydrogel, thermally responsive; ultrasound
Subjects:UNSPECIFIED
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Research Institutes and Centres > Advanced Processing Technology Research Centre (APTRC)
Research Institutes and Centres > I-Form
Publisher:Wiley
Official URL:https://dx.doi.org/10.1002/jbm.b.34820
Copyright Information:© 2021 The Authors. Open Access (CC-BY 4.0)
Funders:Ministry of Higher Education in Kuwait for funding this research.
ID Code:27278
Deposited On:30 May 2022 11:37 by Thomas Murtagh . Last Modified 07 Feb 2024 13:54
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