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Calcium phosphate nanoparticles-based systems for RNAi delivery: applications in bone tissue regeneration

Levingstone, Tanya ORCID: 0000-0002-9751-2314, Herbaj, Simona, Redmond, John ORCID: 0000-0003-2380-7977, McCarthy, Helen O. ORCID: 0000-0002-1254-3745 and Dunne, Nicholas J. ORCID: 0000-0003-4649-2410 (2020) Calcium phosphate nanoparticles-based systems for RNAi delivery: applications in bone tissue regeneration. Nanomaterials, 10 (1). ISSN 2079-4991

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Abstract

Bone-related injury and disease constitute a significant global burden both socially and economically. Current treatments have many limitations and thus the development of new approaches for bone-related conditions is imperative. Gene therapy is an emerging approach for effective bone repair and regeneration, with notable interest in the use of RNA interference (RNAi) systems to regulate gene expression in the bone microenvironment. Calcium phosphate nanoparticles represent promising materials for use as non-viral vectors for gene therapy in bone tissue engineering applications due to their many favorable properties, including biocompatibility, osteoinductivity, osteoconductivity, and strong affinity for binding to nucleic acids. However, low transfection rates present a significant barrier to their clinical use. This article reviews the benefits of calcium phosphate nanoparticles for RNAi delivery and highlights the role of surface functionalization in increasing calcium phosphate nanoparticles stability, improving cellular uptake and increasing transfection efficiency. Currently, the underlying mechanistic principles relating to these systems and their interplay during in vivo bone formation is not wholly understood. Furthermore, the optimal microRNA targets for particular bone tissue regeneration applications are still unclear. Therefore, further research is required in order to achieve the optimal calcium phosphate nanoparticles-based systems for RNAi delivery for bone tissue regeneration

Item Type:Article (Published)
Refereed:Yes
Additional Information:Article number: 146
Uncontrolled Keywords:bone tissue engineering; calcium phosphates; gene therapy; nanoparticles; non-viral vectors; RNA interference; surface functionalization
Subjects:Engineering > Biomedical engineering
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Research Initiatives and Centres > Advanced Processing Technology Research Centre (APTRC)
Publisher:MDPI
Official URL:https://dx.doi.org/10.3390/nano10010146
Copyright Information:© 2020 The Authors. Open Access (CC-BY 4.0)
ID Code:27287
Deposited On:01 Jun 2022 13:39 by Thomas Murtagh . Last Modified 13 Jan 2023 12:00

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