Deciphering the function of the human dihydrofolate
reductase 2 gene
Drago, Paola
(2022)
Deciphering the function of the human dihydrofolate
reductase 2 gene.
PhD thesis, Dublin City University.
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Abstract
DHFR2 is part of the large Dihydrofolate reductase gene family, in which DHFR is the mainly characterised member. For a long time, DHFR was considered the only gene of the family able to make a functional protein, with the remaining members catalogued as pseudogenes. DHFR has been thoroughly studied, considering its crucial role in facilitating the entry of folic acid in the One-Carbon Metabolism pathway, and its implications in neural tube defects and cancer. In the past decade, DHFRP4 was renamed DHFR2 and classified as a protein-coding gene since it harbours an intact open reading frame that can result in a protein, in vitro. However, no information was available in the literature about the endogenous DHFR2 protein, its enzymatic activity, or cellular localisation.
Item Type:
Thesis (PhD)
Date of Award:
November 2022
Refereed:
No
Supervisor(s):
Parle-McDermott, Anne
Uncontrolled Keywords:
DHFR2; Folate; One Carbon Metabolism; DHFR; long noncodingRNA