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Deciphering the function of the human dihydrofolate reductase 2 gene

Drago, Paola (2022) Deciphering the function of the human dihydrofolate reductase 2 gene. PhD thesis, Dublin City University.

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Abstract

DHFR2 is part of the large Dihydrofolate reductase gene family, in which DHFR is the mainly characterised member. For a long time, DHFR was considered the only gene of the family able to make a functional protein, with the remaining members catalogued as pseudogenes. DHFR has been thoroughly studied, considering its crucial role in facilitating the entry of folic acid in the One-Carbon Metabolism pathway, and its implications in neural tube defects and cancer. In the past decade, DHFRP4 was renamed DHFR2 and classified as a protein-coding gene since it harbours an intact open reading frame that can result in a protein, in vitro. However, no information was available in the literature about the endogenous DHFR2 protein, its enzymatic activity, or cellular localisation.

Item Type:Thesis (PhD)
Date of Award:November 2022
Refereed:No
Supervisor(s):Parle-McDermott, Anne
Uncontrolled Keywords:DHFR2; Folate; One Carbon Metabolism; DHFR; long noncodingRNA
Subjects:Biological Sciences > Biochemistry
Biological Sciences > Enzymology
Biological Sciences > Genetics
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
Funders:SFI-BBSRC Joint Funding of Research 17/BBSRC/3416
ID Code:27496
Deposited On:15 Nov 2022 14:59 by Anne Parle-Mcdermott . Last Modified 15 Nov 2022 14:59

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