Calzaferri, Francesco et al (2025) Pharmacological evaluation of non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury. British Journal of Pharmacology . ISSN 1476-5381
Abstract
Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage-associated molecular patterns, such as ATP release,
recognised by P2X7 receptors. The P2X7-NLRP3 inflammasome axis has been identified as one of the main players in neuroinflammation. This study aimed to validate P2X7 receptors as therapeutic target for traumatic brain injury.
Metadata
| Item Type: | Article (Published) |
|---|---|
| Refereed: | Yes |
| Uncontrolled Keywords: | Interleukin-1 beta, neuroinflammation, P2X7 receptor, traumatic brain injury |
| Subjects: | Physical Sciences > Analytical chemistry Physical Sciences > Chemistry |
| DCU Faculties and Centres: | DCU Faculties and Schools > Faculty of Science and Health DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences |
| Publisher: | John Wiley & Sons Ltd. |
| Official URL: | https://bpspubs.onlinelibrary.wiley.com/doi/10.111... |
| Copyright Information: | Authors |
| ID Code: | 31423 |
| Deposited On: | 18 Aug 2025 14:39 by Gordon Kennedy . Last Modified 18 Aug 2025 14:39 |
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