Pellegrin, Yann, Neugebauer, Ute, Devocelle, Marc, Forster, Robert J., Signac, William, Moran, Niamh and Keyes, Tia E. (2008) Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging. Chemical Communications, 2008 (42). pp. 5307-5309. ISSN 1364-548X
Abstract
Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8). Both complexes exhibit long-lived, intense, and oxygen sensitive luminescence. (Ru-R8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for premeablisation of the cell membrane. Such ruthenium polypyridyl peptide conjugates open up the possibility for targeted cell delivery for environmentally sensitive intensity and lifetime imaging.
Metadata
Item Type: | Article (Published) |
---|---|
Refereed: | Yes |
Subjects: | Physical Sciences > Chemistry |
DCU Faculties and Centres: | DCU Faculties and Schools > Faculty of Science and Health > School of Chemical Sciences Research Institutes and Centres > Biomedical Diagnostics Institute (BDI) Research Institutes and Centres > National Centre for Sensor Research (NCSR) |
Publisher: | Royal Society of Chemistry |
Official URL: | http://dx.doi.org/10.1039/b810403d |
Use License: | This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License |
Funders: | Science Foundation Ireland |
ID Code: | 4619 |
Deposited On: | 17 Jun 2009 12:38 by Ciaran McKenna . Last Modified 19 Jul 2018 14:44 |
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