Doctoral Thesis

Bryan, Laura ORCID: 0000-0002-9422-2338 (2021) Investigating phenotype variability between industrially relevant Chinese hamster ovary (CHO) clonally derived cell lines. PhD thesis, Dublin City University.

Capella Roca, Berta (2020) Investigating media supplements to enhance Chinese Hamster ovary cell culture. PhD thesis, Dublin City University.

Coleman, Orla ORCID: 0000-0002-4579-7522 (2019) Application of proteomics to identify proteins involved in pancreatic cancer and to Improve biotherapeutic production in Chinese hamster ovary cells. PhD thesis, Dublin City University.

Henry, Michael (2019) Application of advanced liquid chromatography mass spectrometry to cancer and biopharmaceutical proteomics research. PhD thesis, Dublin City University.

Costello, Alan (2019) RNA manipulations to improve recombinant protein production in Chinese hamster ovary cells. PhD thesis, Dublin City University.

Kellner, Kevin (2018) Improving biopharmaceutical production of Chinese hamster ovary cells using targeted genome engineering Tools. PhD thesis, Dublin City University.

McAuley, Edel (2017) Identification and investigation of novel membrane proteins in colon and pancreatic cancer for potential therapeutic antibody targeting. PhD thesis, Dublin City University.

McCann, Andrew (2016) Identification of membrane associated proteins as potential markers for the DLKP clonal subpopulations. PhD thesis, Dublin City University.

Kelly, Shane (2016) Proteomic characterisation of clonal populations from a humanlung carcinoma cell line. PhD thesis, Dublin City University.

Griffith, Alan (2015) An investigation of novel genetic tools for the manipulation of CHO cell phenotypes during recombinant protein production. PhD thesis, Dublin City University.

Power, Martin (2015) Proteomic profiling of phosphoproteins and secreted proteins from mammalian cell lines in order to gain insights into factors affecting cellular growth and recombinant protein production. PhD thesis, Dublin City University.

Hayes, Catriona Ann (2015) Intrinsic and extrinsic factors affecting proteasome inhibitor resistance in multiple myeloma. PhD thesis, Dublin City University.

Kelly, Paul S. (2014) Enhancing CHO cell productivity through the stable depletion of microRNA-23. PhD thesis, Dublin City University.

Joyce, Helena (2014) Molecular mechanisms of drug resistance and invasion in a human lung carcinoma cell line. PhD thesis, Dublin City University.

Sterritt, Neil (2013) Mutagenesis and directed evolution in CHO cells to improve bio-production characteristics. PhD thesis, Dublin City University.

Sanchez, Noëlia (2013) miRNAs as tools to improve CHO cell bioprocess phenotypes. PhD thesis, Dublin City University.

Rajpal, Rajesh (2012) Investigating biomarkers in clinical samples that are predictive of response in multiple myeloma. PhD thesis, Dublin City University.

Hennessy, Erica (2012) Investigation of pancreatic beta cell differentiation and function, and global profiling analysis of diabetes serum for the identification of disease biomarkers. PhD thesis, Dublin City University.

Reddy Katikireddy, Kishore (2012) Primary culture of human limbal-corneal epithelial cells under different conditions. PhD thesis, Dublin City University.

Ooi, Melissa (2011) Investigation of the intrinsic mechanism of drug resistance in multiple myeloma. PhD thesis, Dublin City University.

O'Sullivan, Dermot (2011) Development of monoclonal antibodies for the identification of novel invasion associated targets in human cancer. PhD thesis, Dublin City University.

Roche, Sandra (2011) Development and application of novel analytical methods for molecularly targeted cancer therapeutics. PhD thesis, Dublin City University.

Corkery, Brendan Martin (2010) Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer. PhD thesis, Dublin City University.

Eustace, Alexander J. (2010) Investigation of response and resistance to dasatinib in melanoma cell lines. PhD thesis, Dublin City University.

Mehta, Jai Prakash (2010) Gene expression analysis in breast cancer. PhD thesis, Dublin City University.

Devery, Aoife (2010) Pharmacological modulation and manipulation of cancer drug resistance. PhD thesis, Dublin City University.

Maurya, Priyanka (2009) Identification of proteins associated with cancerous and invasive phenotypes of breast and melanoma cells using proteomic approaches. PhD thesis, Dublin City University.

Kumar, Niraj (2009) Investigation of the molecular mechanisms regulating growth and recombinant protein productivity in suspension-adapted CHO-K1 cells. PhD thesis, Dublin City University.

Muniyappa, Mohan Kumar (2009) Investigation of the molecular mechanisms underlying the invasive phenotype in a panel of lung cancer cell lines. PhD thesis, Dublin City University.

Rani, Sweta (2009) Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes. PhD thesis, Dublin City University.

Browne, Brigid (2009) The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer. PhD thesis, Dublin City University.

Collins, Denis (2008) Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines. PhD thesis, Dublin City University.

Walsh, Naomi (2008) Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma. PhD thesis, Dublin City University.

Power, Brendan (2006) Alterations in mRNA and protein profiles in eIF4E-transfected human lung carcinoma cells. PhD thesis, Dublin City University.

McKiernan, Eadaoin (2006) An investigation of differentiation programmes governing pancreatic cell development in vitro. PhD thesis, Dublin City University.

Kenny, Elaine (2006) Analysis of messenger RNAs detectable in medium conditioned by tumour cells in serum from breast cancer patients. PhD thesis, Dublin City University.

Martinez, Vanesa (2006) Drug metabolism and chemotherapy resistance. PhD thesis, Dublin City University.

Bray, Isabella (2006) Effects of overexpression of eIF4E and erbB2 on gene expression proflies and invasive phenotype in human cancer cells. PhD thesis, Dublin City University.

Pierce, Aisling (2006) Investigation into the molecular mechanisms underlying invasion in the lung carcinoma cell line DLKP and it's chemotherapeutic drug resistant variants. PhD thesis, Dublin City University.

Bryan, William (2006) Phenotypic and proteomic analysis of 5-Fluorouracil treated normal and carcinoma cells. PhD thesis, Dublin City University.

Murphy, Lisa (2006) The detection of potential drug resistance markers using proteomic technologies. PhD thesis, Dublin City University.

Breen, Laura (2005) Drug resistance, and the role of p53, in lung cancer cell lines. PhD thesis, Dublin City University.

McMorrow, Jason (2004) Transcriptional regulation of chemically induced epithelial lung cell differentiation, in vitro. PhD thesis, Dublin City University.

Linehan, Rasha (2003) The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer. PhD thesis, Dublin City University.

Glynn, Sharon (2002) An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer. PhD thesis, Dublin City University.

Cronin, Deirdre (2002) Investigation of apoptosis-related gene expression in multi-drug resistant cells. PhD thesis, Dublin City University.

Larkin, Anne-Marie (2002) The expression of multiple drug resistance (MDR) associated proteins in invasive breast cancer. PhD thesis, Dublin City University.

Gammell, Patrick (2002) The molecular and cellular biology of pancreatic ß cell differentiation in vitro. PhD thesis, Dublin City University.

Doolan, Padraig (2001) Transcriptional regulation of gene expression in lung carcinoma cells. PhD thesis, Dublin City University.

Touhey, Samantha (2000) Enhancement of the cytotoxicity of MRP substrates by indomethacin and related compounds. PhD thesis, Dublin City University.

O'Loughlin, Colette (1999) Alterations in cell cycle and apoptosis in drug resistant cells. PhD thesis, Dublin City University.

Walsh, Derek (1999) Differentiation of lung cancer cell lines: a role for translational regulation of gene expression. PhD thesis, Dublin City University.

Connolly, Lisa (1999) Generation and characterisation of antibodies specific for the multidrug resistance-associated protein, MRP. PhD thesis, Dublin City University.

O'Sullivan, Finbar (1999) In vitro models of human lung cell differentiation. PhD thesis, Dublin City University.

Liang, Yizheng (1999) Investigation of multidrug resistance and invasion in human cancer cell lines. PhD thesis, Dublin City University.

Blacoe-Masterson, Allan (1998) Investigation of monoclonal antibodies raised to human ovarian carcinoma cell lines. PhD thesis, Dublin City University.

Byrne, Daragh ORCID: 0000-0002-2040-9765 (1998) Investigation of the role of LRP in multidrug resistance. PhD thesis, Dublin City University.

Nic Amhlaoibh, Roisin (1997) Gene expression in the development of multidrug resistance. PhD thesis, Dublin City University.

Elliott, Cathal (1997) Investigations on the role of efflux pumps in drug resistance of human cancer cells. PhD thesis, Dublin City University.

Meleady, Paula ORCID: 0000-0001-5306-310X (1997) Serum-free cell growth and differentiation studies in cultured cell lines. PhD thesis, Dublin City University.

Coyle, Seamus (1996) Chemotherapeutic drug cytotoxicity enhancement in human cells in culture. PhD thesis, Dublin City University.

McBride, Shirley (1995) Characterisation of clonal variants in a human lung carcinoma cell line: investigations into control of growth and differentiation. PhD thesis, Dublin City University.

Cleary, Irene (1995) Drug accumulation studies in multiple drug resistant human cell lines. PhD thesis, Dublin City University.

Gregory, Bernard F. (1994) Autocrine growth control in human carcinoma cells in vitro. PhD thesis, Dublin City University.

Heenan, Mary (1994) Clonal variation in multidrug resistant human cell populations. PhD thesis, Dublin City University.

Keenan, Joanne (1994) Investigation into alternatives to fetal calf serum in animal cell culture. PhD thesis, Dublin City University.

O'Driscoll, Lorraine (1994) Investigation of mechanisms of multiple drug resistance using polymerase chain reaction. PhD thesis, Dublin City University.

Grant, Geraldine (1993) Investigation of xenibiotic metabolism in mammalian cells in culture. PhD thesis, Dublin City University.

Martin, Angela J. (1992) Cytotoxicity testing in vitro: investigation of 5 miniaturized, colorimetric assays. PhD thesis, Dublin City University.

Carey, Breda M. (1992) Production of growth factors from the human carcinoma cell line, RPMI 2650. PhD thesis, Dublin City University.

Redmond, Alice (1991) Multiple drug resistance in human tumor cell lines. PhD thesis, Dublin City University.

Dooley, Margaret (1987) Growth factor production by the human carcinoma cell line RPMI - 2650. PhD thesis, Dublin City University.

Masters Thesis

Solanki, Ankur (2016) microRNAs as potential tools for ‘miR’aculous CHO cell phenotypes in Bioprocessing systems. Master of Science thesis, Dublin City University.

Dunne, Gráinne (2010) Characterisation and modulation of drug resistance in lung cancer cell lines. Master of Science thesis, Dublin City University.

Henry, Michael (2007) Analysis of the effects of BrdU on DLKP human lung cancer cells by two-dimensional difference gel electrophoresis and mass spectrometry. Master of Science thesis, Dublin City University.

Fahey, Catherese (2002) Investigation of largescale production and quantification methodology of monoclonal antibodies (MAbs). Master of Science thesis, Dublin City University.

O'Toole, Angela (1997) An investigation into factors that cause inhibition of the growth of animal cells In Vitro. Master of Science thesis, Dublin City University.

Godfrey, Anne (1988) Clonal variation in growth factor production by human carcinoma cells. Master of Science thesis, Dublin City University.

McManus, Valerie (1986) Anchorage-independent growth of human tumour cells. Master of Engineering thesis, Dublin City University.

Murphy, Edel (1986) Investigation of substitutes for foetal calf serum in animal cell culture media. Master of Science thesis, Dublin City University.