Analysis of biopharma raw materials by electrophoresis microchips with contactless conductivity detection
Vázquez, Mercedes and Benito-Lopez, Fernando and Garcia-Cordero, Jose L. and Ricco, Antonio J. and Diamond, Dermot (2009) Analysis of biopharma raw materials by electrophoresis microchips with contactless conductivity detection. In: μTAS 2009 - 13th International Conference of Miniaturized Systems for Chemistry and Life Science, Micro Total Analysis Systems, 1-5 November 2009, Jeju, Korea. ISBN 978-0-9798064-2-1
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Detailed information concerning the composition of the raw materials employed in the production of biologics is important for the efficient control and optimization of bioprocesses. We demonstrate the application of electrophoresis microchips with capacitively-coupled contactless conductivity detection (C4D) to the analysis of wa-ter-soluble vitamins and metal cations in raw material solutions that are subse-quently fed into bioreactors for the production of biologics.
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