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Probabilistic models for dissolution of ethylcellulose coated microspheres

Bezbradica, Marija and Barat, Ana and Ruskin, Heather and Crane, Martin (2010) Probabilistic models for dissolution of ethylcellulose coated microspheres. In: European Simulation and Modelling Conference 2010, 25-27 Oct 2010, Hasselt, Belgium. ISBN 978-90-77381-57-1

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Abstract

In the last few decades, a number of probabilistic models for drug delivery have been developed. Of particular interest are those that model controlled release systems to provide targeted dose delivery. Controlled release is achieved by using polymers with dierent dissolution characteristics. We present here a model based on Monte Carlo and Cellular Automata approaches, for simulating drug release from coated microspheres in the gastro-intestinal tract. Controlled release is obtained using ethylcellulose as the coating polymer. Modelling features, such as the drug and coating dissolution are nontrivial, since material is non-homogenously dispersed and the dissolution exhibits complex behaviour. Important underlying mechanisms of the process, such as erosion, are described here.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:pharmacokinetics; probabilistic modelling; drug dissolution
Subjects:Biological Sciences > Bioinformatics
Mathematics > Mathematical models
Mathematics > Numerical analysis
Physical Sciences > Statistical physics
Computer Science > Computer simulation
DCU Faculties and Centres:Research Initiatives and Centres > Scientific Computing and Complex Systems Modelling (Sci-Sym)
DCU Faculties and Schools > Faculty of Engineering and Computing > School of Computing
Published in:Proceedings of the European Simulation and Modelling Conference ESM 2010. . Eurosis. ISBN 978-90-77381-57-1
Publisher:Eurosis
Copyright Information:© 2010 Eurosis
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:IRCSET Enterprise Partnership Scheme
ID Code:17638
Deposited On:07 Dec 2012 10:58 by Martin Crane. Last Modified 07 Dec 2012 10:58

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