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Microfluidic lab-in-a-trench platform: cell capture, manipulation and application in glycobiology

Dixit, Chandra and O'Connell, Tríona M. and O'Connor, Brendan and Walls, Dermot and Ducrée, Jens (2013) Microfluidic lab-in-a-trench platform: cell capture, manipulation and application in glycobiology. In: uTAS 2013 , 27-31 Oct 2013, Freiburg, Germany.

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Abstract

Glycans are highly complex carbohydrate molecules and, unlike proteins, they are not encoded by the genome. Instead, they are processed and incorporated at specific locations on proteins and lipids in various combinations at post-translational stages by tightly regulated, enzyme-mediated pathways. Their ability to form complexes within themselves and with other biomolecules, such as proteins, makes them a core component of cellular physiology. Examples of glycan-mediated signaling include embryonic development, cell differentiation and growth, cell-cell recognition, contact inhibition and cell signaling. Glycans therefore constitute an advanced class of information molecules and the full potential of glycan bioprofiling has yet to be realized.

Item Type:Conference or Workshop Item (Paper)
Event Type:Conference
Refereed:Yes
Uncontrolled Keywords:Lab-on-a-Chip; Lab-in-a-Trench
Subjects:Biological Sciences > Biochemistry
Biological Sciences > Microfluidics
Physical Sciences > Nanotechnology
Biological Sciences > Biosensors
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Science and Health > School of Biotechnology
Research Initiatives and Centres > Irish Separation Science Cluster (ISSC)
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. View License
Funders:BIOAT, Science Foundation Ireland
ID Code:19412
Deposited On:05 Nov 2013 14:21 by Brendan O'Connor. Last Modified 13 Feb 2017 11:04

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