Probabilistic models for dissolution of ethylcellulose coated microspheres
Bezbradica, MarijaORCID: 0000-0001-9366-5113, Barat, Ana, Ruskin, Heather J. and Crane, MartinORCID: 0000-0001-7598-3126
(2010)
Probabilistic models for dissolution of ethylcellulose coated microspheres.
In: European Simulation and Modelling Conference 2010, 25-27 Oct 2010, Hasselt, Belgium.
ISBN 978-90-77381-57-1
In the last few decades, a number of probabilistic models
for drug delivery have been developed. Of particular
interest are those that model controlled release systems
to provide targeted dose delivery. Controlled release
is achieved by using polymers with dierent dissolution
characteristics. We present here a model based
on Monte Carlo and Cellular Automata approaches, for
simulating drug release from coated microspheres in the
gastro-intestinal tract. Controlled release is obtained using ethylcellulose as the coating polymer. Modelling features, such as the drug and coating dissolution are nontrivial, since material is non-homogenously dispersed
and the dissolution exhibits complex behaviour. Important
underlying mechanisms of the process, such as
erosion, are described here.
Item Type:
Conference or Workshop Item (Paper)
Event Type:
Conference
Refereed:
Yes
Uncontrolled Keywords:
pharmacokinetics; probabilistic modelling; drug dissolution