Driven by an ever-increasing demand for nanomaterials with specific functionalities, physical synthesis techniques such as Laser Ablation Synthesis in Solution (LASiS) have gained significant interest over in recent years. Commercial wet chemical synthesis methods, while having significantly higher nanomaterial yields than LASiS, typically have considerable negative environmental impact through the use of harmful reagents and solvents. LASiS therefore represents a route towards the sustainable “green” production of nanomaterials however the significant challenge to its commercialization is that of comparably low nanomaterial yields. Significant effort has been made towards increasing the production rates of LASiS, however many of the reported advances have relied on the use of high power (>20 W) or short pulse (<10 ps) laser systems which have high capital costs. Other advances have examined moving from batch production in small volumes towards the use of continuous production through the use of solvent flow systems. Combining these advances, we have developed a new system for nanomaterial generation via LASiS incorporating a low cost, low power (< 4W) Nd:YAG laser and solvent flow system for high-efficiency nanomaterial generation. This study has shown an increase in productivity from 2.5± 0.5 mg/hr for an 11 mL batch colloid, to continuous production yields of 17± 0.7 mg/hr under flow conditions.