Nanotechnology is a significant research tool for biological and medical research with major advancements achieved from nanoparticle (Np) applications in biosensing and biotherapeutics. For laser ablation synthesis in solution (LASiS) to be chosen by researchers for Np colloid production, the process must effectively compete with chemical synthesis in terms of produced colloid quality and productivity while taking advantage of LASiS benefits in terms of its ‘green-synthesis’ and single-step functionalisation abilities. In this work, a newly developed integrated LASiS Np manufacturing system is presented including a Np flow reactor design, an at-line Np size monitoring via 180° dynamic light scattering, and a UV-Vis spectroscopy system used to estimate colloid concentration and stability. The experimental outcomes are discussed in terms of Np productivity and quality via these at-line measurements from the UV-Vis and DLS systems. The developed instrument was validated via off-line SiNps DLS, UV-Vis and morphology tests via TEM. Ultra-high quality and nanoparticle fabrication rate efficiency was achieved and is reported here.
Metadata
Item Type:
Article (Published)
Refereed:
Yes
Additional Information:
Data files are available online: https://doi.org/10.17632/m48784x79n.1.
Science Foundation Ireland (12/IA/1576 and16/RC/3872), European Union’s Horizon 2020 research and innovation programme under grant agreement No. 862000., School of Biotechnology, Dublin City University
ID Code:
25629
Deposited On:
18 Mar 2021 17:22 by
Ronan Mccann
. Last Modified 21 Nov 2023 11:22