Equipped with new powerful and efficient methods for computing quantum expectation values in staticspherically symmetric spacetimes in arbitrary dimensions, we perform an in-depth investigation of how the quantum vacuum polarization varies with the parameters in the theory. In particular, we compute and compare the vacuum polarization for a quantum scalar field in the Schwarzschild–anti–de Sitter black hole spacetime for a range of values of the field mass and field coupling constant as well as the black hole mass and number of spacetime dimensions. In addition, a new approximation for the vacuum polarization in asymptotically anti–de Sitter black hole spacetimes is presented.