Login (DCU Staff Only)
Login (DCU Staff Only)

DORAS | DCU Research Repository

Explore open access research and scholarly works from DCU

Advanced Search

Scale-up of nanoparticle fabrication via laser ablation synthesis in solution

Freeland, Brian orcid logoORCID: 0000-0003-3705-5745 (2020) Scale-up of nanoparticle fabrication via laser ablation synthesis in solution. PhD thesis, Dublin City University.

Throughout the previous decade, extensive advancements have been made in the field of nanomaterial synthesis via laser ablation synthesis in solution (LASiS). In this technique, a solid target is ablated using high-intensity pulsed laser irradiation while immersed in a liquid. This “green” technique allows ligand-free nanoparticles (Nps) to be fabricated without the need for environmentally harmful solvents, paving the way for the production of chemically pure surface coatings. LASiS allows for an in-situ, single-step and post-production surface functionalization, enabling its use in areas such as chemical separation, biosensing, cellular labelling, display technology. Despite these advances, the challenge of reliable production scale-up from batch to continuous production has yet to be realized. A current approach to LASiS scale-up has been to increase average laser power, while minimizing pulse width, resulting in an increased nanoparticle production rate. However, this route on its own has struggled to bridge the commercialization gap with chemical techniques due to the high capital costs of high-power laser systems. In this work, LASiS scale-up has been implemented under continuous flow conditions using low-powered micro-machining laser systems. A 3D printed Nps flow-cell reactor was developed, along with the application of real-time monitoring and control tools to enable autonomous nanoparticle production and characterization. The quality of nano-colloids produced was determined in real-time via atline process analyzers, including dynamic light scattering (DLS) and UV-vis spectroscopy. At-line measurements were validated versus off-line characterization tools, including Transmission Electron Microscopy (TEM). Process optimization of the developed system yielded the highest Np production efficiencies to date in reported in literature for gold, silicon and zinc oxide nanoparticles. This work concludes that high-efficiency, low-cost laser systems can produce Nps that are comparable with wet chemical synthesis, while maintaining the environmental and functional advantages of the LASiS technique.
Item Type:Thesis (PhD)
Date of Award:November 2020
Supervisor(s):Brabazon, Dermot and Foley, Greg
Subjects:Biological Sciences > Biochemistry
Biological Sciences > Microfluidics
Engineering > Materials
Engineering > Mechanical engineering
Physical Sciences > Lasers
Physical Sciences > Nanotechnology
DCU Faculties and Centres:DCU Faculties and Schools > Faculty of Engineering and Computing > School of Mechanical and Manufacturing Engineering
Research Institutes and Centres > Advanced Processing Technology Research Centre (APTRC)
Research Institutes and Centres > I-Form
Use License:This item is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. View License
Funders:Science Foundation Ireland
ID Code:24828
Deposited On:07 Dec 2020 17:30 by Dermot Brabazon . Last Modified 21 Nov 2023 11:31

Full text available as:

[thumbnail of BF_PhD_Thesis_Doras.pdf] PDF - Archive staff only. This file is embargoed until 7 August 2024 - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0


Downloads per month over past year

Archive Staff Only: edit this record